How to Deal with Ion Suppression – the Foe of HPLC-MS/MS
AbstractIt is well accepted, that a HPLC-MS/MS assay can outperform immunoassays in therapeutic drug monitoring (TDM) due to its increased accuracy, sensitivity, and precision. However, the occurrence of sudden and unpredictable ion yield attenuation, can hamper assay performance. Such “ion suppression effects” are considered a central analytical problem if using an MS/MS detector in bio-analysis. Since pathological patient specimen compositions or individual co-medications may be major causes for ion yield fluctuations, measures have to be taken to evaluate these interferences prior to transferring an HPLC-MS/MS assay to routine use.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
SEGER, C.; GRIESMACHER, A. How to Deal with Ion Suppression – the Foe of HPLC-MS/MS. Sci. Pharm. 2009, 77, 170.
SEGER C, GRIESMACHER A. How to Deal with Ion Suppression – the Foe of HPLC-MS/MS. Scientia Pharmaceutica. 2009; 77(Short Lectures (SL)):170.Chicago/Turabian Style
SEGER, C.; GRIESMACHER, A. 2009. "How to Deal with Ion Suppression – the Foe of HPLC-MS/MS." Sci. Pharm. 77, Short Lectures (SL): 170.