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Sci. Pharm.
Volume 77
Issue 4
10.3797/scipharm.0906-12
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney

by
Lili SEPEHR-ARA
1,
Vahab BABAPOOR
2,
Shahrbanoo ORYAN
3 and
Massoud MAHMOUDIAN
4,*
1
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2
Department of Physiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
3
Department of Biology, Science Faculty, Teacher Training University, Tehran, Iran
4
Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(4), 805-816; https://doi.org/10.3797/scipharm.0906-12
Submission received: 24 June 2009 / Accepted: 26 August 2009 / Published: 27 August 2009
Versions Notes

Abstract

In previous researches mebudipine and dibudipine two newly synthesized calcium channel blockers (CCBs) showed considerable relaxant effects on vascular and atrial smooth muscle cells. In this study we investigated the effects of these new drugs on vascular flow of isolated rat kidney and compare their potencies to nifedipine. It is concluded that mebudipine and dibudipine (5 μM, 10 μM) caused concentration-dependent inhibition of increases in perfusion pressure induced by phenylephrine. Mebudipine (10 μM) inhibited more greatly increases in perfusion pressure induced by phenylephrine compared to (10 μM) nifedipine.
Keywords: Mebudipine; Dibudipine; Isolated rat kidney Mebudipine; Dibudipine; Isolated rat kidney

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MDPI and ACS Style

SEPEHR-ARA, L.; BABAPOOR, V.; ORYAN, S.; MAHMOUDIAN, M. Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney. Sci. Pharm. 2009, 77, 805-816. https://doi.org/10.3797/scipharm.0906-12

AMA Style

SEPEHR-ARA L, BABAPOOR V, ORYAN S, MAHMOUDIAN M. Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney. Scientia Pharmaceutica. 2009; 77(4):805-816. https://doi.org/10.3797/scipharm.0906-12

Chicago/Turabian Style

SEPEHR-ARA, Lili, Vahab BABAPOOR, Shahrbanoo ORYAN, and Massoud MAHMOUDIAN. 2009. "Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney" Scientia Pharmaceutica 77, no. 4: 805-816. https://doi.org/10.3797/scipharm.0906-12

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