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Sci. Pharm. 2009, 77(4), 805-816; doi:10.3797/scipharm.0906-12

Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney

1
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
2
Department of Physiology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
3
Department of Biology, Science Faculty, Teacher Training University, Tehran, Iran
4
Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 24 June 2009 / Accepted: 26 August 2009 / Published: 27 August 2009
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Abstract

In previous researches mebudipine and dibudipine two newly synthesized calcium channel blockers (CCBs) showed considerable relaxant effects on vascular and atrial smooth muscle cells. In this study we investigated the effects of these new drugs on vascular flow of isolated rat kidney and compare their potencies to nifedipine. It is concluded that mebudipine and dibudipine (5 μM, 10 μM) caused concentration-dependent inhibition of increases in perfusion pressure induced by phenylephrine. Mebudipine (10 μM) inhibited more greatly increases in perfusion pressure induced by phenylephrine compared to (10 μM) nifedipine.
Keywords: Mebudipine; Dibudipine; Isolated rat kidney Mebudipine; Dibudipine; Isolated rat kidney
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SEPEHR-ARA, L.; BABAPOOR, V.; ORYAN, S.; MAHMOUDIAN, M. Effect of the Two New Calcium Channel Blockers Mebudipine and Dibudipine in Comparison to Nifedipine on Vascular Flow of Isolated Rat Kidney. Sci. Pharm. 2009, 77, 805-816.

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