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Sci. Pharm. 2009, 77(3), 589-596; doi:10.3797/scipharm.0907-16

Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production

1
Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Str., Hanoi, Vietnam
2
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea
*
Author to whom correspondence should be addressed.
Received: 23 July 2009 / Accepted: 6 August 2009 / Published: 6 August 2009
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Abstract

In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.
Keywords: Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

GIANG, P.M.; SON, P.T.; JIN, H.Z.; LEE, J.H.; LEE, J.J. Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production. Sci. Pharm. 2009, 77, 589-596.

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