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Sci. Pharm. 2009, 77(2), 355-366; doi:10.3797/scipharm.0901-20

The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities

1
Faculty of pharmacy, October University for Modern Sciences & Arts, Elwahaat Road, October City, A. R. Egypt
2
Faulty of Science, Chemistry Department, Cairo University, A. R. Egypt
3
National Organization of Drug Control & Research (NODCAR), P.O. 29, Cairo, A. R. Egypt
*
Author to whom correspondence should be addressed.
Received: 18 January 2009 / Accepted: 11 March 2009 / Published: 14 March 2009
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Abstract

The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs.
Keywords: Pyridine; Thiophene; Thiazole; Antimicrobial Pyridine; Thiophene; Thiazole; Antimicrobial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MOHAREB, R.M.; Ezz EL-ARAB, E.; EL-SHARKAWY, K.A. The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities. Sci. Pharm. 2009, 77, 355-366.

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