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Volume 77
Issue 2
10.3797/scipharm.0901-20
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Article

The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities

by
Rafat M. MOHAREB
1,2,*,
Elham Ezz EL-ARAB
3 and
Karam A. EL-SHARKAWY
1
1
Faculty of pharmacy, October University for Modern Sciences & Arts, Elwahaat Road, October City, A. R. Egypt
2
Faulty of Science, Chemistry Department, Cairo University, A. R. Egypt
3
National Organization of Drug Control & Research (NODCAR), P.O. 29, Cairo, A. R. Egypt
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(2), 355-366; https://doi.org/10.3797/scipharm.0901-20
Submission received: 18 January 2009 / Accepted: 11 March 2009 / Published: 14 March 2009
Versions Notes

Abstract

The hydrazide-hydrazone derivative 1 was formed through the reaction of cyanoacetic acid hydrazide with 2-acetylfuran. Compound 1 underwent a series of hetrocyclization reactions through its reaction with different chemical reagents to produce arylidene, coumarin, aryl hydrazone, pyridine, thiophene and thiazole derivatives 2–10. The MIC values for the newly synthesized products were tested against E. coli, B. cereus, B. subtilis and C. albicans compared with ampicilline and cycloheximide as reference drugs.
Keywords: Pyridine; Thiophene; Thiazole; Antimicrobial Pyridine; Thiophene; Thiazole; Antimicrobial

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MDPI and ACS Style

MOHAREB, R.M.; Ezz EL-ARAB, E.; EL-SHARKAWY, K.A. The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities. Sci. Pharm. 2009, 77, 355-366. https://doi.org/10.3797/scipharm.0901-20

AMA Style

MOHAREB RM, Ezz EL-ARAB E, EL-SHARKAWY KA. The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities. Scientia Pharmaceutica. 2009; 77(2):355-366. https://doi.org/10.3797/scipharm.0901-20

Chicago/Turabian Style

MOHAREB, Rafat M., Elham Ezz EL-ARAB, and Karam A. EL-SHARKAWY. 2009. "The Reaction of Cyanoacetic Acid Hydrazide with 2-Acetylfuran: Synthesis of Coumarin, Pyridine, Thiophene and Thiazole Derivatives with Potential Antimicrobial Activities" Scientia Pharmaceutica 77, no. 2: 355-366. https://doi.org/10.3797/scipharm.0901-20

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