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Sci. Pharm. 2009, 77(2), 343-354; doi:10.3797/scipharm.0812-07

Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent

1
Radiolabeling Lab, Nuclear Medicine Research Group, Agricultural, Medical and Industrial Research School (AMIRS), Moazzen Blvd., Rajaeeshahr, P.O.Box: 31485-498, Karaj, Iran
2
Faculty of Pharmacy, Islamic Azad University, Tehran, Iran
*
Author to whom correspondence should be addressed.
Received: 5 December 2008 / Accepted: 5 March 2009 / Published: 6 March 2009
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Abstract

[67Ga]labeled 2-acetylpyridine 4,4-dimethylthiosemicarbazone ([67Ga]- [APTSM2]2+) was prepared using freshly prepared [67Ga]GaCl3 and 2-acetylpyridine 4,4-dimethylthiosemicarbazone (APTSM2) for 30 min at 90°C (radiochemical purity: >97% ITLC, >98% HPLC, specific activity: 15–20 Ci/mmol). Stability of the complex was checked in human serum for 37°C. The biodistribution of the labeled compound in vital organs of normal and fibrosarcoma bearing mice were compared with that of free Ga3+ cation up to 24h. Initial SPECT images and biodistribution results showed significant tumor uptake in fibrosarcoma-bearing mice after 2 hour post injection.
Keywords: 67Ga-complexation; Thiosemicarbazone; Biodistribution; SPECT; Fibrosarcoma 67Ga-complexation; Thiosemicarbazone; Biodistribution; SPECT; Fibrosarcoma
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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JALILIAN, A.R.; MEHDIPOUR, P.; AKHLAGHI, M.; YOUSEFNIA, H.; SHAFAII, K. Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Sci. Pharm. 2009, 77, 343-354.

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