Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent
Abstract[67Ga]labeled 2-acetylpyridine 4,4-dimethylthiosemicarbazone ([67Ga]- [APTSM2]2+) was prepared using freshly prepared [67Ga]GaCl3 and 2-acetylpyridine 4,4-dimethylthiosemicarbazone (APTSM2) for 30 min at 90°C (radiochemical purity: >97% ITLC, >98% HPLC, specific activity: 15–20 Ci/mmol). Stability of the complex was checked in human serum for 37°C. The biodistribution of the labeled compound in vital organs of normal and fibrosarcoma bearing mice were compared with that of free Ga3+ cation up to 24h. Initial SPECT images and biodistribution results showed significant tumor uptake in fibrosarcoma-bearing mice after 2 hour post injection.
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JALILIAN, A.R.; MEHDIPOUR, P.; AKHLAGHI, M.; YOUSEFNIA, H.; SHAFAII, K. Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Sci. Pharm. 2009, 77, 343-354.
JALILIAN AR, MEHDIPOUR P, AKHLAGHI M, YOUSEFNIA H, SHAFAII K. Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent. Scientia Pharmaceutica. 2009; 77(2):343-354.Chicago/Turabian Style
JALILIAN, Amir R.; MEHDIPOUR, Pegah; AKHLAGHI, Mehdi; YOUSEFNIA, Hassan; SHAFAII, Kamaledin. 2009. "Evaluation of a [67Ga]-Thiosemicarbazone Complex as Tumor Imaging Agent." Sci. Pharm. 77, no. 2: 343-354.