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Sci. Pharm. 2009, 77(1), 67-78; doi:10.3797/scipharm.0812-12

Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin

1
Department of Analytical Research, Discovery Research, Dr. Reddy’s Laboratories, Miyapur, Hyderabad 500 049, India
2
Process R&D, Custom pharmaceutical synthesis-II, Dr. Reddy’s Laboratories Ltd., Jeedimetla, Hyderabad, India
3
Jawaharlal Nehru Technological University, Kukatpally, Hyderabad-500072, India
*
Author to whom correspondence should be addressed.
Received: 31 December 2008 / Accepted: 4 February 2009 / Published: 5 February 2009
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Abstract

During the synthesis of Sparfloxacin, a fluoroquinolone antibiotic drug, an unknown impurity (SF5-IMP) was identified in the fifth stage of the synthetic process. The impurity has been isolated from the mother liquor of intermediate SF5. The mother liquor was concentrated to dryness added dichloromethane and stirred for 1 h and filtered to generate SF5-IMP and the molecular structure was elucidated as 7-amino-1-cyclopropyl-5,6,8-trifluoro-4-oxo-1,4-dihydroquinoline- 3-carboxylic acid by 19F NMR and single crystal X-ray diffraction studies. The structural features of SF5-IMP and SF5 have been discussed here.
Keywords: Sparfloxacin; 1H NMR; 19F NMR; Single crystal X-ray diffraction Sparfloxacin; 1H NMR; 19F NMR; Single crystal X-ray diffraction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

MUNIGELA, N.; BABU J., M.; YERRAMILLI, A.; VISHWESHWAR, P.; YADDANAPUDI SESHA SIVA, G.Y.S.S.; VALAVALA, N.M. Isolation and Characterization of an Impurity Obtained During the Synthesis of the Antibiotic Drug Sparfloxacin. Sci. Pharm. 2009, 77, 67-78.

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