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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Volume were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(1), 33-46; doi:10.3797/scipharm.0810-01 (registering DOI)

Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach

1
Mahakal Institute of Pharmaceutical Studies, Rajiv Gandhi Technical University Behind Air Strip Datana Deaws Road Ujjain 456664 (M.P.) India
2
B. R. Nahata College of Pharmacy, Department of Medicinal Chemistry, Rajiv Gandhi Technical University, Mhow-Neemuch Road 458001 Mandsaur (M.P.) India
3
School of Pharmacy Devi Ahilya Vishwavidylaya, Takshashila Parisar Khandwa road, 452003 Indore (M.P.) India
*
Author to whom correspondence should be addressed.
Received: 10 October 2008 / Accepted: 13 January 2009 / Published: 14 January 2009
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Abstract

In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl- 4-(biphenylylmethoxy)quinolines as angiotensin II (Ang II) receptor antagonists by using Chem 3D and Dragon Software. The studies, carried out on 33 analogs, give statistically significant correlations of selective Ang II antagonistic activity with physical properties concerning size, symmetry, shape and distribution of molecule atoms. Among several 2D quantitative structure activity relationship models, one model gave good statistical significance (r > 0.81, Ftest = 10.47, S < 0.30, chance correlation < 0.01). 3D QSAR studies show that Hennery’s law constant, Dipole and VDWE play a significant role in Ang II antagonistic activity. These QSAR studies help us in the design and prediction of novel substituted benzimidazole Ang II receptor antagonists.
Keywords: QSAR; Angiotensin II antagonists; Hypertension; AT1 and AT2 receptor QSAR; Angiotensin II antagonists; Hypertension; AT1 and AT2 receptor
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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VYAS, V.K.; JAIN, A.; MAHAJAN, S.C.; PATIDAR, R.; MISTRY, S.; CHATURVEDI, S.C. Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach. Sci. Pharm. 2009, 77, 33-46.

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