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Sci. Pharm. 2009, 77(1), 1-8; doi:10.3797/scipharm.0901-14 (registering DOI)

Short Total Synthesis of the Marine Alkaloid Subarine

Department Pharmazie – Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Butenandtstr. 5–13, 81377 München, Germany
Author to whom correspondence should be addressed.
Received: 9 January 2009 / Accepted: 4 February 2009 / Published: 5 February 2009
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The marine benzo[c][2,7]naphthyridine alkaloid subarine is prepared in 4 steps, starting from commercially available 1,10-phenanthroline, via oxidative cleavage to the bipyridine-dicarboxylate, conversion to the mono(2-iodoanilide), and radical cyclization. The alkaloid does not show any significant antimicrobial or cytotoxic activity.
Keywords: Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products Subarine; Alkaloid; Radical cyclization; Benzo[c][2,7]naphthyridine; Marine natural products
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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LOTTER, M.; BRACHER, F. Short Total Synthesis of the Marine Alkaloid Subarine. Sci. Pharm. 2009, 77, 1-8.

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