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Sci. Pharm. 2007, 75(4), 147-164; doi:10.3797/scipharm.2007.75.147 (registering DOI)

Factors Influencing Drug Dissolution Characteristic from Hydrophilic Polymer Matrix Tablet

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, 50200, Thailand
2
Department of Pharmaceutical Technology and Biopharmaceutics, University of Vienna, A-1090, Austria
*
Author to whom correspondence should be addressed.
Received: 28 October 2007 / Accepted: 1 December 2007 / Published: 31 December 2007
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Abstract

The aim of this work was to investigate the factors influencing the dissolution characteristics of drug substances from hydrophilic polymer matrix tablets. Various kinds of cellulose derivative polymers were used in for matrix formation. Their swelling propertiesy waswere measured. The effects on drug release was firstly carried were studiedout in comparison with lactose. Results showedindicate that drug release characteristics from polymer matrix tablets followed a Higuchi square root time kinetics. It was found that the polymers could retard the release of drugs in both simulated gastric fluid (SGF) and simulated intestinal fluid (SIF), but at different levels. The dissolution constants of drugs exhibitedwere higher when the pH of the dissolution medium was increased. Results also demonstratedindicate a the linear correlation between the proportions of matrix-forming structures in the tablets and the extent of dissolution retardation. It was found that not only the swelling property of the polymer but also its hydrophobicity and the hardness of the tablet played an important role onin the retardation of drug release. Results also revealedindicate that PVP K30 could supports cellulose polymers so as to improve the release behavior in order keep a better control to maintain a constant drug release in each time interval.in order to better keep drug release constant in each time interval.
Keywords: Pentoxifylline; Ketoprofen; sustained release; tablet; HPMC; PVP Pentoxifylline; Ketoprofen; sustained release; tablet; HPMC; PVP
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saeio, K.; Pongpaibul, Y.; Viernstein, H.; Okonogi, S. Factors Influencing Drug Dissolution Characteristic from Hydrophilic Polymer Matrix Tablet. Sci. Pharm. 2007, 75, 147-164.

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