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Sci. Pharm. 2007, 75(3), 121-146; doi:10.3797/scipharm.2007.75.121 (registering DOI)

Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7)

1
Dept. of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, Amman11942, Jordan
2
Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan
*
Author to whom correspondence should be addressed.
Received: 2 July 2007 / Accepted: 9 September 2007 / Published: 28 September 2007
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Abstract

76 ethanolic extracts of medicinal herbs from the Jordanian flora, belonging to 67 species and 34 families, were evaluated for their antiproliferative activity on a breast cancer cell line (MCF7). The cells were cultured in RPMI 1640 medium and incubated with the extracts for 72 hours. Sulphorhodamine B (SRB) assay was used to test cytotoxicity.
From the tested crude extracts, Inula graveolens, Salvia dominica, Conyza canadiensis and Achillea santolina showed potent antiproliferative activity and the activity resided in the chloroform/ethanolic extracts. The most active plant was I. graveolens with an IC50 of 3.83 μg/ml. Phytochemical screening indicated the presence of flavonoids, terpenoids, and phenolics in all active extracts. These results indicate the possible potential use of medicinal plants from the Jordanian flora as antineoplastic agents.
Keywords: Antiproliferative activity; SRB; Medicinal plants; Jordan; MCF7 Antiproliferative activity; SRB; Medicinal plants; Jordan; MCF7
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Abu-Dahab, R.; Afifi, F. Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7). Sci. Pharm. 2007, 75, 121-146.

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