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Sci. Pharm. 2007, 75(2), 81-96; doi:10.3797/scipharm.2007.75.81 (registering DOI)

Study of Local Anaesthetics. Part 172* Comparison of the Influence of Auxilliary Substances on Physicochemical Parameters of Two Phenylcarbamic Acid Derivatives

1
Department of Galenic Pharmacy, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovak Republic
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, 832 32 Bratislava, Slovak Republic
*
Author to whom correspondence should be addressed.
Received: 16 February 2007 / Accepted: 9 March 2007 / Published: 29 June 2007
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Abstract

It this work was studied the influence of polyols (propylene glycol, glycerol and sorbitol) on the physicochemical parameters (partition coefficient and surface tension) and liberation from aqueous solutions with propylene glycol of two derivatives of phenylcarbamic acid. Studied parameters and liberation were influenced by the structure of the studied derivatives and with the type and concentration of polyols.
Keywords: artition coefficient; surface tension; derivative of phenylcarbamic acids; in vitro liberation artition coefficient; surface tension; derivative of phenylcarbamic acids; in vitro liberation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Gardavská, K.; Čižmárik, J.; Žabka, M. Study of Local Anaesthetics. Part 172* Comparison of the Influence of Auxilliary Substances on Physicochemical Parameters of Two Phenylcarbamic Acid Derivatives. Sci. Pharm. 2007, 75, 81-96.

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