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Sci. Pharm. 2007, 75(2), 55-62; doi:10.3797/scipharm.2007.75.55 (registering DOI)

The Antimycobacterial Derivatives against Potential Pathogenic Strains: 2-Hydroxy-3-(4-phenylpiperazin-1-yl)-propylphenylcarbamates

1
Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, CZ-500 05 Hradec Králové, Czech Republic
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Comenius University, Odbojárov 10, SK 832 32 Bratislava. Slovak Republic
3
Reference Laboratory for Mycobacterium knasasii, Regional Institute of Public Health in Ostrava, Partyzánské nám. 7, CZ 702 00 Ostrava, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 13 February 2007 / Accepted: 14 March 2007 / Published: 29 June 2007
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Abstract

According to our previous study 29 derivatives of 2-hydroxy-3-(4-phenylpiperazin-1-yl)-propylphenylcarbamates were tested for in vitro antimycobacterial activity against potential pathogenic strains Mycobacterium kansasii and Mycobacterium avium. The variations in group of compounds were by the substitution on phenyl rings. The Free-Wilson method was used to evaluate structure-antimycobacterial activity relationships. The advantage of compounds under study is in the activity against M. kansasii.
Keywords: Carbamates; propylphenylcarbamates; mycobacterium; potential pathogenic strains Carbamates; propylphenylcarbamates; mycobacterium; potential pathogenic strains
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Waisser, K.; Doležal, R.; Čižmárik, J.; Malík, I.; Kaustová, J. The Antimycobacterial Derivatives against Potential Pathogenic Strains: 2-Hydroxy-3-(4-phenylpiperazin-1-yl)-propylphenylcarbamates. Sci. Pharm. 2007, 75, 55-62.

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