Next Article in Journal
Biomarkers in Lysosomal Storage Diseases
Previous Article in Journal
Developing a Research Instrument to Document Awareness, Knowledge, and Attitudes Regarding Breast Cancer and Early Detection Techniques for Pakistani Women: The Breast Cancer Inventory (BCI)
Article Menu

Export Article

Open AccessArticle
Diseases 2016, 4(4), 38; doi:10.3390/diseases4040038

Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases

1
Department of Gastroenterology and Nephrology, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan
2
Japan Community Health care Organization Funabashi Central Hospital, 6-13-10 Kaijin, Funabashi, Chiba 273-8556, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Catassi
Received: 2 November 2016 / Revised: 7 December 2016 / Accepted: 9 December 2016 / Published: 14 December 2016
(This article belongs to the Section Gastroenterology)
View Full-Text   |   Download PDF [2403 KB, uploaded 14 December 2016]   |  

Abstract

Background: Wisteria floribunda agglutinin-positive human Mac-2-binding protein (WFA(+)-M2BP) is a novel non-invasive marker of liver fibrosis. The goal of the study was to investigate whether the novel serum biomarker WFA(+)-M2BP or other non-invasive markers are useful for the prediction of liver fibrosis in patients with nonalcoholic steatohepatitis (NASH), autoimmune hepatitis (AIH), and primary biliary cholangitis (PBC). Methods: We examined a significant correlation between serum WFA(+)-M2BP levels and histological staging of fibrosis in several chronic liver diseases, such as NASH, AIH, and PBC. Results: WFA(+)-M2BP could not predict hepatic fibrosis in these patients. We also showed that the level of platelet counts is a useful predictor of hepatic fibrosis progression in patients with NASH, AIH, and PBC. There was a significant correlation between staging of fibrosis and grading of activity in the liver in all groups except for AIH patients. Conclusion: Platelet counts can predict hepatic fibrosis in patients with NASH, AIH, or PBC. Clinicians should pay attention to the grading of liver activity in the use of WFA(+)-M2BP. View Full-Text
Keywords: autoimmune hepatitis; nonalcoholic steatohepatitis; primary biliary cholangitis; WFA(+)-M2BP; M2BPGi autoimmune hepatitis; nonalcoholic steatohepatitis; primary biliary cholangitis; WFA(+)-M2BP; M2BPGi
Figures

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Haga, Y.; Kanda, T.; Sasaki, R.; Nakamura, M.; Takahashi, K.; Wu, S.; Yasui, S.; Arai, M.; Nakamoto, S.; Yokosuka, O. Serum Wisteria Floribunda Agglutinin-Positive Mac-2 Binding Protein Could Not Always Predict Early Cirrhosis in Non-Viral Liver Diseases. Diseases 2016, 4, 38.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diseases EISSN 2079-9721 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top