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Diseases 2016, 4(2), 21; doi:10.3390/diseases4020021

Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins

1
Center for Excellence in Post-Harvest Technologies, North Carolina Research Campus, North Carolina Agricultural and Technical State University, Kannapolis, NC 28081, USA
2
School of Nutrition & Food Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 29 February 2016 / Revised: 11 April 2016 / Accepted: 22 April 2016 / Published: 28 April 2016
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Abstract

Proanthocyanidins are oligomeric flavonoids found in plant sources, most notably in apples, cinnamon, grape skin and cocoa beans. They have been also found in substantial amounts in cranberry, black currant, green tea, black tea and peanut skins. These compounds have been recently investigated for their health benefits. Proanthocyanidins have been demonstrated to have positive effects on various metabolic disorders such as inflammation, obesity, diabetes and insulin resistance. Another upcoming area of research that has gained widespread interest is microRNA (miRNA)-based anticancer therapies. MicroRNAs are short non-coding RNA segments, which plays a crucial role in RNA silencing and post-transcriptional regulation of gene expression. Currently, miRNA based anticancer therapies are being investigated either alone or in combination with current treatment methods. In this review, we summarize the current knowledge and investigate the potential of naturally occurring proanthocyanidins in modulating miRNA expression. We will also assess the strategies and challenges of using this approach as potential cancer therapeutics. View Full-Text
Keywords: proanthocyanidins; microRNA; cancer; polyphenols proanthocyanidins; microRNA; cancer; polyphenols
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bansode, R.R.; Khatiwada, J.R.; Losso, J.N.; Williams, L.L. Targeting MicroRNA in Cancer Using Plant-Based Proanthocyanidins. Diseases 2016, 4, 21.

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