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Electronics 2015, 4(4), 879-908; doi:10.3390/electronics4040879

Organic Bioelectronic Tools for Biomedical Applications

Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, SE-171-77 Stockholm, Sweden
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Author to whom correspondence should be addressed.
Academic Editors: Ruth Shinar and Emil J. W. List-Kratochvil
Received: 22 September 2015 / Revised: 23 October 2015 / Accepted: 26 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Recent Advances in Organic Bioelectronics and Sensors)
View Full-Text   |   Download PDF [1472 KB, uploaded 5 November 2015]   |  

Abstract

Organic bioelectronics forms the basis of conductive polymer tools with great potential for application in biomedical science and medicine. It is a rapidly growing field of both academic and industrial interest since conductive polymers bridge the gap between electronics and biology by being electronically and ionically conductive. This feature can be employed in numerous ways by choosing the right polyelectrolyte system and tuning its properties towards the intended application. This review highlights how active organic bioelectronic surfaces can be used to control cell attachment and release as well as to trigger cell signaling by means of electrical, chemical or mechanical actuation. Furthermore, we report on the unique properties of conductive polymers that make them outstanding materials for labeled or label-free biosensors. Techniques for electronically controlled ion transport in organic bioelectronic devices are introduced, and examples are provided to illustrate their use in self-regulated medical devices. Organic bioelectronics have great potential to become a primary platform in future bioelectronics. We therefore introduce current applications that will aid in the development of advanced in vitro systems for biomedical science and of automated systems for applications in neuroscience, cell biology and infection biology. Considering this broad spectrum of applications, organic bioelectronics could lead to timely detection of disease, and facilitate the use of remote and personalized medicine. As such, organic bioelectronics might contribute to efficient healthcare and reduced hospitalization times for patients. View Full-Text
Keywords: organic bioelectronics; nanomedicine; regenerative medicine; drug delivery; tissue engineering; tissue microbiology organic bioelectronics; nanomedicine; regenerative medicine; drug delivery; tissue engineering; tissue microbiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Löffler, S.; Libberton, B.; Richter-Dahlfors, A. Organic Bioelectronic Tools for Biomedical Applications. Electronics 2015, 4, 879-908.

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