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Biology 2018, 7(3), 41; https://doi.org/10.3390/biology7030041

Building Principles for Constructing a Mammalian Blastocyst Embryo

School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand
Received: 13 June 2018 / Revised: 19 July 2018 / Accepted: 20 July 2018 / Published: 23 July 2018
(This article belongs to the Special Issue Reproductive Biology)
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Abstract

The self-organisation of a fertilised egg to form a blastocyst structure, which consists of three distinct cell lineages (trophoblast, epiblast and hypoblast) arranged around an off-centre cavity, is unique to mammals. While the starting point (the zygote) and endpoint (the blastocyst) are similar in all mammals, the intervening events have diverged. This review examines and compares the descriptive and functional data surrounding embryonic gene activation, symmetry-breaking, first and second lineage establishment, and fate commitment in a wide range of mammalian orders. The exquisite detail known from mouse embryogenesis, embryonic stem cell studies and the wealth of recent single cell transcriptomic experiments are used to highlight the building principles underlying early mammalian embryonic development. View Full-Text
Keywords: lineage determination; patterning; blastomere polarization; compaction; cleavage stages; morula; gene regulatory networks lineage determination; patterning; blastomere polarization; compaction; cleavage stages; morula; gene regulatory networks
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Pfeffer, P.L. Building Principles for Constructing a Mammalian Blastocyst Embryo. Biology 2018, 7, 41.

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