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Biology 2017, 6(2), 23; doi:10.3390/biology6020023

Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation

Faculty of Pharma-Sciences, Teikyo University, 2-11-1 Kaga, Itabashi-Ku, Tokyo 173-8605, Japan
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Academic Editor: Chris O’Callaghan
Received: 8 November 2016 / Revised: 23 March 2017 / Accepted: 24 March 2017 / Published: 30 March 2017
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Abstract

The coenzyme A (CoA)-independent transacylation system catalyzes fatty acid transfer from phospholipids to lysophospholipids in the absence of cofactors such as CoA. It prefers to use C20 and C22 polyunsaturated fatty acids such as arachidonic acid, which are esterified in the glycerophospholipid at the sn-2 position. This system can also acylate alkyl ether-linked lysophospholipids, is involved in the enrichment of arachidonic acid in alkyl ether-linked glycerophospholipids, and is critical for the metabolism of eicosanoids and platelet-activating factor. Despite their importance, the enzymes responsible for these reactions have yet to be identified. In this review, we describe the features of the Ca2+-independent, membrane-bound CoA-independent transacylation system and its selectivity for arachidonic acid. We also speculate on the involvement of phospholipase A2 in the CoA-independent transacylation reaction. View Full-Text
Keywords: CoA-independent transacylation system; acyltransferase; phospholipase A2; lysophospholipid; lysophospholipase/transacylation; platelet-activating factor; alkyl-ether linked phospholipid; eicosanoid; cPLA2γ CoA-independent transacylation system; acyltransferase; phospholipase A2; lysophospholipid; lysophospholipase/transacylation; platelet-activating factor; alkyl-ether linked phospholipid; eicosanoid; cPLA2γ
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yamashita, A.; Hayashi, Y.; Matsumoto, N.; Nemoto-Sasaki, Y.; Koizumi, T.; Inagaki, Y.; Oka, S.; Tanikawa, T.; Sugiura, T. Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation. Biology 2017, 6, 23.

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