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Biology 2017, 6(1), 10; doi:10.3390/biology6010010

Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications

1
Department of Laboratory Medicine, Division of Clinical Chemistry, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm 14186, Sweden
2
Department of Biology and Biotechnology “Charles Darwin”, Sapienza University of Rome, Rome 00185, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Chris O’Callaghan
Received: 1 October 2016 / Revised: 10 January 2017 / Accepted: 23 January 2017 / Published: 4 February 2017
View Full-Text   |   Download PDF [293 KB, uploaded 4 February 2017]

Abstract

Over recent years, a deeper comprehension of the molecular mechanisms that control biological clocks and circadian rhythms has been achieved. In fact, many studies have contributed to unravelling the importance of the molecular clock for the regulation of our physiology, including hormonal and metabolic homeostasis. Here we will review the structure, organisation and molecular machinery that make our circadian clock work, and its relevance for the proper functioning of physiological processes. We will also describe the interconnections between circadian rhythms and endocrine homeostasis, as well as the underlying consequences that circadian dysregulations might have in the development of several pathologic affections. Finally, we will discuss how a better knowledge of such relationships might prove helpful in designing new therapeutic approaches for endocrine and metabolic diseases. View Full-Text
Keywords: circadian clock; central oscillator; peripheral oscillators; hormonal homeostasis; metabolic diseases circadian clock; central oscillator; peripheral oscillators; hormonal homeostasis; metabolic diseases
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gnocchi, D.; Bruscalupi, G. Circadian Rhythms and Hormonal Homeostasis: Pathophysiological Implications. Biology 2017, 6, 10.

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