Next Article in Journal
Differentiation of Crohn’s Disease-Associated Isolates from Other Pathogenic Escherichia coli by Fimbrial Adhesion under Shear Force
Previous Article in Journal
Melatonin and Sleep-Wake Rhythms before and after Ocular Lens Replacement in Elderly Humans
Previous Article in Special Issue
Endocrine and Local IGF-I in the Bony Fish Immune System
Article Menu

Export Article

Open AccessReview
Biology 2016, 5(1), 13; doi:10.3390/biology5010013

Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Brian Dixon
Received: 18 December 2015 / Revised: 1 March 2016 / Accepted: 1 March 2016 / Published: 8 March 2016
(This article belongs to the Special Issue Current Topics in Fish Immunity)
View Full-Text   |   Download PDF [1086 KB, uploaded 8 March 2016]   |  

Abstract

Across vertebrates, innate immunity consists of a complex assortment of highly specialized cells capable of unleashing potent effector responses designed to destroy or mitigate foreign pathogens. The execution of various innate cellular behaviors such as phagocytosis, degranulation, or cell-mediated cytotoxicity are functionally indistinguishable when being performed by immune cells isolated from humans or teleost fishes; vertebrates that diverged from one another more than 450 million years ago. This suggests that vital components of the vertebrate innate defense machinery are conserved and investigating such processes in a range of model systems provides an important opportunity to identify fundamental features of vertebrate immunity. One characteristic that is highly conserved across vertebrate systems is that cellular immune responses are dependent on specialized immunoregulatory receptors that sense environmental stimuli and initiate intracellular cascades that can elicit appropriate effector responses. A wide variety of immunoregulatory receptor families have been extensively studied in mammals, and many have been identified as cell- and function-specific regulators of a range of innate responses. Although much less is known in fish, the growing database of genomic information has recently allowed for the identification of several immunoregulatory receptor gene families in teleosts. Many of these putative immunoregulatory receptors have yet to be assigned any specific role(s), and much of what is known has been based solely on structural and/or phylogenetic relationships with mammalian receptor families. As an attempt to address some of these shortcomings, this review will focus on our growing understanding of the functional roles played by specific members of the channel catfish (Ictalurus punctatus) leukocyte immune-type receptors (IpLITRs), which appear to be important regulators of several innate cellular responses via classical as well as unique biochemical signaling networks. View Full-Text
Keywords: teleost; immunoregulatory receptors; channel catfish; leukocyte immune-type receptors; innate immunity; phagocytosis; intracellular signaling; functional plasticity; tyrosine-based signaling motifs teleost; immunoregulatory receptors; channel catfish; leukocyte immune-type receptors; innate immunity; phagocytosis; intracellular signaling; functional plasticity; tyrosine-based signaling motifs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Fei, C.; Pemberton, J.G.; Lillico, D.M.E.; Zwozdesky, M.A.; Stafford, J.L. Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors. Biology 2016, 5, 13.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top