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Biology 2015, 4(3), 494-511; doi:10.3390/biology4030494

The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs

Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
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Author to whom correspondence should be addressed.
Academic Editor: Chris O'Callaghan
Received: 5 June 2015 / Revised: 22 July 2015 / Accepted: 23 July 2015 / Published: 28 July 2015
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Abstract

MicroRNAs (miRNAs) are small, non-coding RNAs that have the ability to post-transcriptionally regulate gene expression. Hundreds of miRNAs have been identified in humans and they are involved in the regulation of almost every process, including cholesterol transport, metabolism, and maintenance of cholesterol homeostasis. Because of their small size and their ability to very specifically regulate gene expression, miRNAs are attractive targets for the regulation of dyslipidemias and other lipid-related disorders. However, the complex interactions between miRNAs, transcription factors, and gene expression raise great potential for side effects as a result of miRNA overexpression or inhibition. Many dietary components can also target specific miRNAs, altering the expression of downstream genes. Therefore, much more research is necessary to fully understand the role(s) of each miRNA in the body and how they may be impacted by diet and health. The present review aims to summarize the known roles of miRNAs in the regulation of reverse cholesterol transport and the maintenance of cholesterol homeostasis, as well as the potential clinical consequences of their manipulation. View Full-Text
Keywords: miRNA; plasma lipoproteins; reverse cholesterol transport; cholesterol homeostasis miRNA; plasma lipoproteins; reverse cholesterol transport; cholesterol homeostasis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

DiMarco, D.M.; Fernandez, M.L. The Regulation of Reverse Cholesterol Transport and Cellular Cholesterol Homeostasis by MicroRNAs. Biology 2015, 4, 494-511.

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