Biology 2013, 2(3), 841-860; doi:10.3390/biology2030841
Review

Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili

Received: 12 April 2013; in revised form: 21 May 2013 / Accepted: 24 May 2013 / Published: 26 June 2013
(This article belongs to the Special Issue Bacterial Adhesion)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process.
Keywords: chaperone-usher pathway; type I and P pilus; chaperone; usher; donor-strand complementation; donor-strand exchange; pilicide
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MDPI and ACS Style

Lillington, J.; Waksman, G. Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili. Biology 2013, 2, 841-860.

AMA Style

Lillington J, Waksman G. Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili. Biology. 2013; 2(3):841-860.

Chicago/Turabian Style

Lillington, James; Waksman, Gabriel. 2013. "Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili." Biology 2, no. 3: 841-860.

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