Next Article in Journal
A Versatile Tool for Stable Inhibition of microRNA Activity
Next Article in Special Issue
Structural Sampling of Glycan Interaction Profiles Reveals Mucosal Receptors for Fimbrial Adhesins of Enterotoxigenic Escherichia coli
Previous Article in Journal
Marine Invertebrates: Communities at Risk
Previous Article in Special Issue
Adhesion of Diarrheagenic Escherichia coli and Inhibition by Glycocompounds Engaged in the Mucosal Innate Immunity
Article Menu

Export Article

Open AccessReview
Biology 2013, 2(3), 841-860; doi:10.3390/biology2030841

Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili

Institute of Structural and Molecular Biology, University College London and Birkbeck College, Malet Street, London, WC1E 7HX, UK
*
Author to whom correspondence should be addressed.
Received: 12 April 2013 / Revised: 21 May 2013 / Accepted: 24 May 2013 / Published: 26 June 2013
(This article belongs to the Special Issue Bacterial Adhesion)
View Full-Text   |   Download PDF [712 KB, uploaded 26 June 2013]   |  

Abstract

Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit folding and maintains them in a polymerization-competent state, and an outer membrane-spanning nanomachine, the usher, which choreographs their assembly into a pilus and drives their secretion through the membrane. In this review, recent structures and kinetic studies are combined to examine the mechanism of type I and P pili assembly, as it is currently known. We also investigate how the knowledge of pilus biogenesis mechanisms has been exploited to design selective inhibitors of the process. View Full-Text
Keywords: chaperone-usher pathway; type I and P pilus; chaperone; usher; donor-strand complementation; donor-strand exchange; pilicide chaperone-usher pathway; type I and P pilus; chaperone; usher; donor-strand complementation; donor-strand exchange; pilicide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lillington, J.; Waksman, G. Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili. Biology 2013, 2, 841-860.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top