Next Article in Journal / Special Issue
Comparison of Engineered Peptide-Glycosaminoglycan Microfibrous Hybrid Scaffolds for Potential Applications in Cartilage Tissue Regeneration
Previous Article in Journal
Kinetics of Thermally Activated Physical Processes in Disordered Media
Previous Article in Special Issue
Electrospun Scaffolds from Low Molecular Weight Poly(ester amide)s Based on Glycolic Acid, Adipic Acid and Odd or Even Diamines
Article Menu

Export Article

Open AccessArticle
Fibers 2015, 3(3), 253-264; doi:10.3390/fib3030253

Investigating the Influence of Extracellular Matrix and Glycolytic Metabolism on Muscle Stem Cell Migration on Their Native Fiber Environment

1
School of Biological Sciences, University of Reading, Reading RG6 6UB, UK
2
Department of Agricultural, Food and Environmental Sciences, University of Perugia, Perugia I-06121, Italy
3
Department of Cell and Molecular Biology, Scripps Research Institute, La Jolla, CA 92037, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jingwei Xie
Received: 2 June 2015 / Accepted: 8 July 2015 / Published: 16 July 2015
(This article belongs to the Special Issue Fibers for Biomedical Applications)
View Full-Text   |   Download PDF [383 KB, uploaded 16 July 2015]   |  

Abstract

The composition of the extracellular matrix (ECM) of skeletal muscle fibers is a unique environment that supports the regenerative capacity of satellite cells; the resident stem cell population. The impact of environment has great bearing on key properties permitting satellite cells to carry out tissue repair. In this study, we have investigated the influence of the ECM and glycolytic metabolism on satellite cell emergence and migration—two early processes required for muscle repair. Our results show that both influence the rate at which satellite cells emerge from the sub-basal lamina position and their rate of migration. These studies highlight the necessity of performing analysis of satellite behavior on their native substrate and will inform on the production of artificial scaffolds intended for medical uses. View Full-Text
Keywords: muscle; fiber; satellite; blebbing; myostatin; migration muscle; fiber; satellite; blebbing; myostatin; migration
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Butera, G.; Collins-Hooper, H.; Mitchell, R.; Makarenkova, H.P.; Lasagna, E.; Patel, K. Investigating the Influence of Extracellular Matrix and Glycolytic Metabolism on Muscle Stem Cell Migration on Their Native Fiber Environment. Fibers 2015, 3, 253-264.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Fibers EISSN 2079-6439 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top