Next Article in Journal
CuO and CuO/Graphene Nanostructured Thin Films as Counter Electrodes for Pt-Free Dye-Sensitized Solar Cells
Previous Article in Journal
Surface Free Energy Utilization to Evaluate Wettability of Hydrocolloid Suspension on Different Vegetable Epicarps
Previous Article in Special Issue
Electrophoretic Deposition as a New Bioactive Glass Coating Process for Orthodontic Stainless Steel
Article Menu
Issue 1 (January) cover image

Export Article

Open AccessArticle
Coatings 2018, 8(1), 17; doi:10.3390/coatings8010017

Effects of Immobilizations of rhBMP-2 and/or rhPDGF-BB on Titanium Implant Surfaces on Osseointegration and Bone Regeneration

1
Department of Prosthodontics, Dental Research Institute, Institute of Translational Dental Sciences, BK21 PLUS Project, School of Dentistry, Pusan National University, 49 Pusan University-Ro, Yangsan-Si 50612, Gyeongsangnam-Do, Korea
2
Department of Orthopedic Surgery and Rare Diseases Institute, Korea University Medical College, Guro Hospital, #80, Guro-dong, Guro-gu, Seoul 08308, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 23 November 2017 / Revised: 28 December 2017 / Accepted: 30 December 2017 / Published: 31 December 2017
(This article belongs to the Special Issue Surface Engineering of Biomaterials)
View Full-Text   |   Download PDF [4372 KB, uploaded 31 December 2017]   |  

Abstract

The aim of this study was to examine the effects of immobilizing rhPDGF-BB plus rhBMP-2 on heparinized-Ti implants on in vivo osseointegration and vertical bone regeneration at alveolar ridges. Successful immobilizations of rhPDGF-BB and/or rhBMP-2 onto heparinized-Ti (Hepa/Ti) were confirmed by in vitro analysis, and both growth factors were found to be sustained release. To evaluate bone regeneration, rhPDGF-BB, and/or rhBMP-2-immobilized Hepa/Ti implants were inserted into beagle dogs; implant stability quotients (ISQ), bone mineral densities, bone volumes, osseointegration, and bone formation were assessed by micro CT and histometrically. In vivo study showed that the osseointegration and bone formation were greater in the rhPDGF-BB/rhBMP-2-immobilized Hepa/Ti group than in the rhPDGF-BB-immobilized Hepa/Ti group. The rhPDGF-BB/rhBMP-2 immobilized Hepa/Ti group also showed better implant stability and greater bone volume around defect areas and intra-thread bone density (ITBD) than the rhBMP-2-immobilized Hepa/Ti group. However, no significant differences were observed between these two groups. Through these results, we conclude rhBMP-2 immobilized, heparin-grafted implants appear to offer a suitable delivery system that enhances new bone formation in defect areas around implants. However, we failed to observe the synergetic effects for the rhBMP-2 and rhPDGF-BB combination. View Full-Text
Keywords: rhBMP-2; rhPDGF-BB; heparin; implant surface; osseointegration; bone regeneration; beagle dog rhBMP-2; rhPDGF-BB; heparin; implant surface; osseointegration; bone regeneration; beagle dog
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Lee, S.-H.; Bae, E.-B.; Kim, S.-E.; Yun, Y.-P.; Kim, H.-J.; Choi, J.-W.; Lee, J.-J.; Huh, J.-B. Effects of Immobilizations of rhBMP-2 and/or rhPDGF-BB on Titanium Implant Surfaces on Osseointegration and Bone Regeneration. Coatings 2018, 8, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Coatings EISSN 2079-6412 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top