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Antibiotics 2018, 7(3), 64; https://doi.org/10.3390/antibiotics7030064

Antibiotic Targets in Gonococcal Cell Wall Metabolism

Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA
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Received: 27 June 2018 / Revised: 19 July 2018 / Accepted: 19 July 2018 / Published: 21 July 2018
(This article belongs to the Special Issue Multi-Drug Resistant Neisseria gonorrhoeae)
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Abstract

The peptidoglycan cell wall that encloses the bacterial cell and provides structural support and protection is remodeled by multiple enzymes that synthesize and cleave the polymer during growth. This essential and dynamic structure has been targeted by multiple antibiotics to treat gonococcal infections. Up until now, antibiotics have been used against the biosynthetic machinery and the therapeutic potential of inhibiting enzymatic activities involved in peptidoglycan breakdown has not been explored. Given the major antibiotic resistance problems we currently face, it is crucial to identify other possible targets that are key to maintaining cell integrity and contribute to disease development. This article reviews peptidoglycan as an antibiotic target, how N. gonorrhoeae has developed resistance to currently available antibiotics, and the potential of continuing to target this essential structure to combat gonococcal infections by attacking alternative enzymatic activities involved in cell wall modification and metabolism. View Full-Text
Keywords: peptidoglycan; Neisseria gonorrhoeae; lytic transglycosylase peptidoglycan; Neisseria gonorrhoeae; lytic transglycosylase
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Pérez Medina, K.M.; Dillard, J.P. Antibiotic Targets in Gonococcal Cell Wall Metabolism. Antibiotics 2018, 7, 64.

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