Surveillance for Antimicrobial Resistance in Gonorrhea: The Alberta Model, 2012–2016
AbstractAlberta established a surveillance system in 2001 to monitor resistance to antibiotics used for the treatment of gonorrhea. A retrospective review of gonorrhea cases during the last five years was conducted. All cases of gonorrhea were reportable to public health by testing laboratories and clinicians. Specimens were primarily submitted for nucleic acid amplification testing (NAAT); three sentinel sites obtained specimens for culture and NAAT. The Provincial Laboratory for Public Health conducted E-tests on isolates for multiple antibiotics. A proportion of isolates and NAAT specimens were submitted to the National Microbiology Laboratory for sequence typing (ST). Data were combined and analyzed using SAS version 9.4. Between 2012 and 2016, 13,132 gonorrhea cases were reported; 22.0% (n = 2891) had isolates available for susceptibility testing. All culture positive isolates were susceptible to ceftriaxone. Decreased susceptibility (0.5 ug/mL) to cefixime was reported in four cases in 2014. Resistance to azithromycin (≥2 ug/mL) ranged between 0.4% and 1.8%. Many (n = 509) unique STs were identified; the most prevalent sequence groups (SG) were SG-7638 (n = 367), SG-5985 (n = 145), and SG-11299 (n = 127). The Alberta model for maintaining surveillance for antimicrobial resistance in gonorrhea employs culture and NAAT specimens, providing information crucial to informing provincial treatment guidelines. View Full-Text
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Gratrix, J.; Kamruzzaman, A.; Martin, I.; Smyczek, P.; Read, R.; Bertholet, L.; Naidu, P.; Singh, A.E. Surveillance for Antimicrobial Resistance in Gonorrhea: The Alberta Model, 2012–2016. Antibiotics 2018, 7, 63.
Gratrix J, Kamruzzaman A, Martin I, Smyczek P, Read R, Bertholet L, Naidu P, Singh AE. Surveillance for Antimicrobial Resistance in Gonorrhea: The Alberta Model, 2012–2016. Antibiotics. 2018; 7(3):63.Chicago/Turabian Style
Gratrix, Jennifer; Kamruzzaman, Anmmd; Martin, Irene; Smyczek, Petra; Read, Ron; Bertholet, Lindsay; Naidu, Prenilla; Singh, Ameeta E. 2018. "Surveillance for Antimicrobial Resistance in Gonorrhea: The Alberta Model, 2012–2016." Antibiotics 7, no. 3: 63.
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