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Actinomycetes, an Inexhaustible Source of Naturally Occurring Antibiotics
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Antibiotics 2018, 7(2), 47; https://doi.org/10.3390/antibiotics7020047

Novel Polyethers from Screening Actinoallomurus spp.

1
NAICONS Srl, Viale Ortles 22/4, 20139 Milano, Italy
2
KtedoGen Srl, Viale Ortles 22/4, 20139 Milano, Italy
*
Author to whom correspondence should be addressed.
Received: 1 May 2018 / Revised: 12 June 2018 / Accepted: 13 June 2018 / Published: 14 June 2018
(This article belongs to the Special Issue Actinomycetes: The Antibiotics Producers)
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Abstract

In screening for novel antibiotics, an attractive element of novelty can be represented by screening previously underexplored groups of microorganisms. We report the results of screening 200 strains belonging to the actinobacterial genus Actinoallomurus for their production of antibacterial compounds. When grown under just one condition, about half of the strains produced an extract that was able to inhibit growth of Staphylococcus aureus. We report here on the metabolites produced by 37 strains. In addition to previously reported aminocoumarins, lantibiotics and aromatic polyketides, we described two novel and structurally unrelated polyethers, designated α-770 and α-823. While we identified only one producer strain of the former polyether, 10 independent Actinoallomurus isolates were found to produce α-823, with the same molecule as main congener. Remarkably, production of α-823 was associated with a common lineage within Actinoallomurus, which includes A. fulvus and A. amamiensis. All polyether producers were isolated from soil samples collected in tropical parts of the world. View Full-Text
Keywords: Actinoallomurus; antibiotics polyethers; screening Actinoallomurus; antibiotics polyethers; screening
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Iorio, M.; Tocchetti, A.; Cruz, J.C.S.; Del Gatto, G.; Brunati, C.; Maffioli, S.I.; Sosio, M.; Donadio, S. Novel Polyethers from Screening Actinoallomurus spp.. Antibiotics 2018, 7, 47.

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