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Antibiotics 2018, 7(1), 22; https://doi.org/10.3390/antibiotics7010022

Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids

Stable Solutions LLC, Goleta, CA 93117, USA
Received: 8 February 2018 / Revised: 5 March 2018 / Accepted: 9 March 2018 / Published: 10 March 2018
View Full-Text   |   Download PDF [491 KB, uploaded 12 March 2018]   |  

Abstract

The incidence of antimicrobial resistance (AMR) worldwide is increasing as the pipeline for the development of new chemotherapeutic entities is decreasing. Clearly, overexposure to antibiotics, including excessive dosing, is a key factor that fuels AMR. In fact, most of the new antibacterial agents under development are derivatives of existing classes of antibiotics. Novel approaches involving unique antimicrobial combinations, targets, and/or delivery systems are under intense investigation. An innovative combination of active pharmaceutical ingredients (APIs) consisting of antimicrobial drug(s), krill-oil-based phospholipids, and omega-3 fatty acid triglycerides, that may extend the therapeutic viability of currently effective antibiotics, at least until new chemical entities are introduced, is described. View Full-Text
Keywords: β-lactam antibiotics; β-lactamase inhibitors; krill oil phospholipids; omega-3 fatty acid triglycerides; antimicrobial resistance β-lactam antibiotics; β-lactamase inhibitors; krill oil phospholipids; omega-3 fatty acid triglycerides; antimicrobial resistance
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Driscoll, D.F. Potentially Important Therapeutic Interactions between Antibiotics, and a Specially Engineered Emulsion Drug Vehicle Containing Krill-Oil-Based Phospholipids and Omega-3 Fatty Acids. Antibiotics 2018, 7, 22.

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