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Antibiotics 2017, 6(4), 39; doi:10.3390/antibiotics6040039

Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece

1
Dermatology Department, Andreas Sygros University Skin Hospital, 16121 Athens, Greece
2
Microbiology Department, Andreas Sygros University Skin Hospital, 16121 Athens, Greece
3
Department of Statistics and Mathematics, National Technical University of Athens, 15780 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 8 November 2017 / Revised: 14 December 2017 / Accepted: 19 December 2017 / Published: 20 December 2017
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Abstract

Objective: To determine the prevalence of resistant strains of Staphylococcus aureus (S. aureus) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospital with a skin infection between the years 2010–2015 were examined retrospectively. Bacterial cultures, identification of S. aureus and antimicrobial susceptibility testing were performed using the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines and European Committee on Antimicrobial testing (EUCAST) breakpoints. EUCAST breakpoints were applied if no CLSI were available. Results: Of 2069 S. aureus isolates identified, 1845 (88%) were resistant to one or more antibiotics. The highest resistance was observed for benzylpenicillin (71.9%), followed by erythromycin (34.3%). Resistant strains to cefoxitin defined as MRSA (methicillin-resistant S. aureus) represented 21% of total isolates. Interestingly, resistance to fusidic acid was 22.9% and to mupirocin as high as 12.7%. Low rates were observed for minocycline, rifampicin and trimethoprim/sulfamethoxazole (SXT). Resistance to antibiotics remained relatively stable throughout the six-year period, with the exception of cefoxitin, fusidic acid and SXT. A high percentage of MRSA strains were resistant to erythromycin (60%), fusidic acid (46%), clindamycin (38%) and tetracycline (35.5%). Conclusions: Special attention is required in prescribing appropriate antibiotic therapeutic regimens, particularly for MRSA. These data on the susceptibility of S. aureus may be useful for guiding antibiotic treatment. View Full-Text
Keywords: Staphylococcus aureus; MRSA; cefoxitin; mupirocin; fusidic acid; resistance Staphylococcus aureus; MRSA; cefoxitin; mupirocin; fusidic acid; resistance
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Stefanaki, C.; Ieronymaki, A.; Matoula, T.; Caroni, C.; Polythodoraki, E.; Chryssou, S.-E.; Kontochristopoulos, G.; Antoniou, C. Six-Year Retrospective Review of Hospital Data on Antimicrobial Resistance Profile of Staphylococcus aureus Isolated from Skin Infections from a Single Institution in Greece. Antibiotics 2017, 6, 39.

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