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Open AccessOpinion
Antibiotics 2017, 6(4), 32; doi:10.3390/antibiotics6040032

Is Genetic Mobilization Considered When Using Bacteriophages in Antimicrobial Therapy?

Department of Genetics, Microbiology and Statistics, Faculty of Biology, Av. Diagonal 643, 08028 Barcelona, Spain
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Received: 5 September 2017 / Revised: 15 November 2017 / Accepted: 4 December 2017 / Published: 5 December 2017
(This article belongs to the Special Issue Bacteriophages: Alternatives to Antibiotics and Beyond)
View Full-Text   |   Download PDF [228 KB, uploaded 5 December 2017]

Abstract

The emergence of multi-drug resistant bacteria has undermined our capacity to control bacterial infectious diseases. Measures needed to tackle this problem include controlling the spread of antibiotic resistance, designing new antibiotics, and encouraging the use of alternative therapies. Phage therapy seems to be a feasible alternative to antibiotics, although there are still some concerns and legal issues to overcome before it can be implemented on a large scale. Here we highlight some of those concerns, especially those related to the ability of bacteriophages to transport bacterial DNA and, in particular, antibiotic resistance genes. View Full-Text
Keywords: bacteriophages; antimicrobials; lysins; horizontal gene transfer, transduction bacteriophages; antimicrobials; lysins; horizontal gene transfer, transduction
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rodríguez-Rubio, L.; Jofre, J.; Muniesa, M. Is Genetic Mobilization Considered When Using Bacteriophages in Antimicrobial Therapy? Antibiotics 2017, 6, 32.

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