Ribosome Assembly as Antimicrobial Target
AbstractMany antibiotics target the ribosome and interfere with its translation cycle. Since translation is the source of all cellular proteins including ribosomal proteins, protein synthesis and ribosome assembly are interdependent. As a consequence, the activity of translation inhibitors might indirectly cause defective ribosome assembly. Due to the difficulty in distinguishing between direct and indirect effects, and because assembly is probably a target in its own right, concepts are needed to identify small molecules that directly inhibit ribosome assembly. Here, we summarize the basic facts of ribosome targeting antibiotics. Furthermore, we present an in vivo screening strategy that focuses on ribosome assembly by a direct fluorescence based read-out that aims to identify and characterize small molecules acting as primary assembly inhibitors. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 725 KB)
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Nikolay, R.; Schmidt, S.; Schlömer, R.; Deuerling, E.; Nierhaus, K.H. Ribosome Assembly as Antimicrobial Target. Antibiotics 2016, 5, 18.
Nikolay R, Schmidt S, Schlömer R, Deuerling E, Nierhaus KH. Ribosome Assembly as Antimicrobial Target. Antibiotics. 2016; 5(2):18.Chicago/Turabian Style
Nikolay, Rainer; Schmidt, Sabine; Schlömer, Renate; Deuerling, Elke; Nierhaus, Knud H. 2016. "Ribosome Assembly as Antimicrobial Target." Antibiotics 5, no. 2: 18.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.