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Antibiotics 2016, 5(2), 18; doi:10.3390/antibiotics5020018

Ribosome Assembly as Antimicrobial Target

1
Institut für Medizinische Physik und Biophysik, Charité—Universitätsmedizin Berlin, 10117 Berlin, Germany
2
Molecular Microbiology, University of Konstanz, Konstanz 78457, Germany
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Claudio O. Gualerzi
Received: 31 March 2016 / Revised: 2 May 2016 / Accepted: 16 May 2016 / Published: 27 May 2016
(This article belongs to the Special Issue Inhibitors of the Translational Apparatus)
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Abstract

Many antibiotics target the ribosome and interfere with its translation cycle. Since translation is the source of all cellular proteins including ribosomal proteins, protein synthesis and ribosome assembly are interdependent. As a consequence, the activity of translation inhibitors might indirectly cause defective ribosome assembly. Due to the difficulty in distinguishing between direct and indirect effects, and because assembly is probably a target in its own right, concepts are needed to identify small molecules that directly inhibit ribosome assembly. Here, we summarize the basic facts of ribosome targeting antibiotics. Furthermore, we present an in vivo screening strategy that focuses on ribosome assembly by a direct fluorescence based read-out that aims to identify and characterize small molecules acting as primary assembly inhibitors. View Full-Text
Keywords: protein synthesis as preferential target of antibiotics; ribosome as antibiotic target; inhibitors of ribosome assembly; concepts for identifying assembly inhibitors protein synthesis as preferential target of antibiotics; ribosome as antibiotic target; inhibitors of ribosome assembly; concepts for identifying assembly inhibitors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nikolay, R.; Schmidt, S.; Schlömer, R.; Deuerling, E.; Nierhaus, K.H. Ribosome Assembly as Antimicrobial Target. Antibiotics 2016, 5, 18.

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