Next Article in Journal
Remote Antimicrobial Stewardship in Community Hospitals
Next Article in Special Issue
Microarray Evaluation of Antimicrobial Resistance and Virulence of Escherichia coli Isolates from Portuguese Poultry
Previous Article in Journal
Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies
Previous Article in Special Issue
Livestock-Associated MRSA: The Impact on Humans
Article Menu

Export Article

Open AccessReview
Antibiotics 2015, 4(4), 567-604; doi:10.3390/antibiotics4040567

Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens

Department of Bacteriology and Food Safety, Animal and Plant Health Agency (Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Martin J. Woodward
Received: 10 August 2015 / Revised: 5 November 2015 / Accepted: 6 November 2015 / Published: 13 November 2015
(This article belongs to the Special Issue The Use of Antibiotics in Food-Producing Animals)
View Full-Text   |   Download PDF [825 KB, uploaded 13 November 2015]

Abstract

Concerns have been raised in recent years regarding co-selection for antibiotic resistance among bacteria exposed to biocides used as disinfectants, antiseptics and preservatives, and to heavy metals (particularly copper and zinc) used as growth promoters and therapeutic agents for some livestock species. There is indeed experimental and observational evidence that exposure to these non-antibiotic antimicrobial agents can induce or select for bacterial adaptations that result in decreased susceptibility to one or more antibiotics. This may occur via cellular mechanisms that are protective across multiple classes of antimicrobial agents or by selection of genetic determinants for resistance to non-antibiotic agents that are linked to genes for antibiotic resistance. There may also be relevant effects of these antimicrobial agents on bacterial community structure and via non-specific mechanisms such as mobilization of genetic elements or mutagenesis. Notably, some co-selective adaptations have adverse effects on fitness in the absence of a continued selective pressure. The present review examines the evidence for the significance of these phenomena, particularly in respect of bacterial zoonotic agents that commonly occur in livestock and that may be transmitted, directly or via the food chain, to human populations. View Full-Text
Keywords: biocide; heavy metal; antimicrobial resistance; zoonoses biocide; heavy metal; antimicrobial resistance; zoonoses
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Wales, A.D.; Davies, R.H. Co-Selection of Resistance to Antibiotics, Biocides and Heavy Metals, and Its Relevance to Foodborne Pathogens. Antibiotics 2015, 4, 567-604.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top