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Antibiotics 2015, 4(4), 424-434; doi:10.3390/antibiotics4040424

An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA)

Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Christopher C. Butler
Received: 25 July 2015 / Revised: 15 September 2015 / Accepted: 22 September 2015 / Published: 9 October 2015
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Abstract

The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health crisis worldwide. In particular, meticillin-resistant Staphylococcus aureus (MRSA), a pathogen responsible for numerous human infections, has become endemic in hospitals worldwide. Drug repurposing, the finding of new therapeutic indications for approved drugs, is deemed a plausible solution to accelerate drug discovery and development in this area. Towards this end, we screened 1163 drugs approved by the Food and Drug Administration (FDA) for bioactivities against MRSA in a 10 μM single-point assay. After excluding known antibiotics and antiseptics, six compounds were identified and their MICs were determined against a panel of clinical MRSA strains. A toxicity assay using human keratinocytes was also conducted to gauge their potential for repurposing as topical agents for treating MRSA skin infections. View Full-Text
Keywords: drug library screen; drug repurposing; drug repositioning; MRSA drug library screen; drug repurposing; drug repositioning; MRSA
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lau, Q.Y.; Tan, Y.Y.F.; Goh, V.C.Y.; Lee, D.J.Q.; Ng, F.M.; Ong, E.H.Q.; Hill, J.; Chia, C.S.B. An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA). Antibiotics 2015, 4, 424-434.

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