Next Article in Journal / Special Issue
NETs and CF Lung Disease: Current Status and Future Prospects
Previous Article in Journal
Acknowledgement to Reviewers of Antibiotics in 2014
Previous Article in Special Issue
Mechanisms of Antimicrobial Peptide Resistance in Gram-Negative Bacteria
Article Menu

Export Article

Open AccessReview
Antibiotics 2015, 4(1), 44-61; doi:10.3390/antibiotics4010044

Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections

Department of Microbiology and Immunology, F. Edward Hébert School of Medicine, Uniformed Services University of Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA
Present address: National Innovation Foundation, Department of Science and Technology, Government of India, Near Grambharati Circle, Amrapur, Gandhinagar, Gujarat 382721, India
*
Author to whom correspondence should be addressed.
Academic Editor: William M. Shafer
Received: 4 October 2014 / Accepted: 23 December 2014 / Published: 12 January 2015
(This article belongs to the Special Issue Antimicrobial Peptides)
View Full-Text   |   Download PDF [677 KB, uploaded 12 January 2015]   |  

Abstract

The emergence of antibiotic resistance seriously threatens our ability to treat many common and medically important bacterial infections. Novel therapeutics are needed that can be used alone or in conjunction with antibiotics. Cationic antimicrobial peptides (CAMPs) are important effectors of the host innate defense that exhibit broad-spectrum activity against a wide range of microorganisms. CAMPs are carried within phagocytic granules and are constitutively or inducibly expressed by multiple cell types, including epithelial cells. The role of histone modification enzymes, specifically the histone deacetylases (HDAC), in down-regulating the transcription of CAMP-encoding genes is increasingly appreciated as is the capacity of HDAC inhibitors (HDACi) to block the action of HDACs to increase CAMP expression. The use of synthetic and natural HDACi molecules to increase CAMPs on mucosal surfaces, therefore, has potential therapeutic applications. Here, we review host and pathogen regulation of CAMP expression through the induction of HDACs and assess the therapeutic potential of natural and synthetic HDACi based on evidence from tissue culture systems, animal models, and clinical trials. View Full-Text
Keywords: chromatin remodeling; histone deacetylase inhibitors; antimicrobial peptides; bacterial infections; anti-infectives chromatin remodeling; histone deacetylase inhibitors; antimicrobial peptides; bacterial infections; anti-infectives
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Yedery, R.D.; Jerse, A.E. Augmentation of Cationic Antimicrobial Peptide Production with Histone Deacetylase Inhibitors as a Novel Epigenetic Therapy for Bacterial Infections. Antibiotics 2015, 4, 44-61.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top