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Antibiotics 2014, 3(1), 29-38; doi:10.3390/antibiotics3010029
Article

Antibiotic Prescribing in Primary Care and Antimicrobial Resistance in Patients Admitted to Hospital with Urinary Tract Infection: A Controlled Observational Pilot Study

1,* , 2
, 3
, 4
 and 5
Received: 23 December 2013; in revised form: 10 January 2014 / Accepted: 15 January 2014 / Published: 22 January 2014
(This article belongs to the Special Issue Antibiotics and Urinary Tract Infections)
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Abstract: There is growing evidence that primary care prescribed antibiotics lead to antibiotic resistance in bacteria causing minor infections or being carried by asymptomatic adults, but little research to date has investigated links between primary care prescribed antibiotics and resistance among more serious infections requiring hospital care. Knowledge of these effects is likely to have a major influence on public expectations for, and primary care use of, antibiotics. This study aimed to assess the feasibility of recruiting symptomatic adult patients admitted to hospital with urinary infections and to link primary and secondary data information to investigate the relationship between primary care prescribed antibiotics and antimicrobial resistance in these patients. A microbiology database search of in patients who had submitted a urine sample identified 740 patients who were potentially eligible to take part in the study. Of these, 262 patients did not meet the eligibility criteria, mainly due to use of a urinary catheter (40%). Two-hundred and forty three patients could not be recruited as the nurse was unable to visit the patients prior to discharge, as they were too unwell. Eighty patients provided complete information. Results indicate that there is evidence that prior antibiotic use is associated with resistant infections in hospital patients. A fully powered study, conducted using routinely collected data is proposed to fully clarify the precision of the association.
Keywords: antibiotics; primary care; antimicrobial resistance; urinary tract infection antibiotics; primary care; antimicrobial resistance; urinary tract infection
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Costelloe, C.; Williams, O.M.; Montgomery, A.A.; Dayan, C.; Hay, A.D. Antibiotic Prescribing in Primary Care and Antimicrobial Resistance in Patients Admitted to Hospital with Urinary Tract Infection: A Controlled Observational Pilot Study. Antibiotics 2014, 3, 29-38.

AMA Style

Costelloe C, Williams OM, Montgomery AA, Dayan C, Hay AD. Antibiotic Prescribing in Primary Care and Antimicrobial Resistance in Patients Admitted to Hospital with Urinary Tract Infection: A Controlled Observational Pilot Study. Antibiotics. 2014; 3(1):29-38.

Chicago/Turabian Style

Costelloe, Ceire; Williams, O. M.; Montgomery, Alan A.; Dayan, Colin; Hay, Alastair D. 2014. "Antibiotic Prescribing in Primary Care and Antimicrobial Resistance in Patients Admitted to Hospital with Urinary Tract Infection: A Controlled Observational Pilot Study." Antibiotics 3, no. 1: 29-38.

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