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Biosensors 2018, 8(2), 49; https://doi.org/10.3390/bios8020049

Consistency of Continuous Ambulatory Interstitial Glucose Monitoring Sensors

1
Division of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90024, USA
2
Department of Geriatrics, David Geffen School of Medicine at UCLA and Geriatric Research Education and Clinical Center (GRECC), VA Greater Los Angeles Healthcare System, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Received: 16 April 2018 / Revised: 11 May 2018 / Accepted: 14 May 2018 / Published: 16 May 2018
(This article belongs to the Special Issue Continuous Glucose Monitoring)
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Abstract

Aims: The abdominal region is the most common location for continuous glucose monitor (CGM) sensor insertion. However, a paucity of post-marketing data is available to demonstrate intra-individual consistency of CGM readings at different abdominal insertion sites. Methods: Healthy adults (fasting glucose (FG) < 5.5 mmol/L; BMI < 30 kg/m2) were recruited and a CGM sensor was placed on each side of the abdomen. Postprandial and continuous 48-h interstitial glucose levels were analyzed. Results: There was no significant difference in the 3-h postprandial glucose (PPG) level derived from the left versus right CGM, which remained non-significant after adjusting for waist circumference or FG. Among the glucose levels recorded over 48-h, values on the left site were greater in 3.6% of the data points (p < 0.05). After adjusting for waist circumference, only 0.5% of the glucose values remained significantly greater on the left (p < 0.05). When adjusted for FG, similar results were observed. For both PPG and 48-h readings, the mean absolute relative difference was not significant between the two abdominal sites. Conclusions: CGM-derived glucose measures were highly consistent between the left and right abdomen during both the postprandial and post-absorptive periods. View Full-Text
Keywords: continuous glucose monitoring; interstitial glucose sensors; intra-subject agreement; postprandial glucose continuous glucose monitoring; interstitial glucose sensors; intra-subject agreement; postprandial glucose
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wu, P.T.; Segovia, D.E.; Lee, C.C.; Nguyen, K.-L. Consistency of Continuous Ambulatory Interstitial Glucose Monitoring Sensors. Biosensors 2018, 8, 49.

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