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Biosensors 2018, 8(2), 45; https://doi.org/10.3390/bios8020045

Droplet Velocity Measurement Based on Dielectric Layer Thickness Variation Using Digital Microfluidic Devices

Department of Electrical and Electronic Engineering, Universiti Teknologi PETRONAS, Seri Iskander 32610, Malaysia
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Received: 27 February 2018 / Revised: 22 March 2018 / Accepted: 22 March 2018 / Published: 8 May 2018
(This article belongs to the Special Issue Micro and Nanoscale Biosensors)
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Abstract

In recent years, the number of interdisciplinary research works related to the development of miniaturized systems with integrated chemical and biological analyses is increasing. Digital microfluidic biochips (DMFBs) are one kind of miniaturized systems designed for conducting inexpensive, fast, convenient and reliable biochemical assay procedures focusing on basic scientific research and medical diagnostics. The role of a dielectric layer in the digital microfluidic biochips is prominent as it helps in actuating microliter droplets based on the electrowetting-on-dielectric (EWOD) technique. The advantages of using three different material layers of dielectric such as parafilm, polytetrafluoroethylene (PTFE) and ethylene tetrafluoroethylene (ETFE) were reported in the current work. A simple fabrication process of a digital microfluidic device was performed and good results were obtained. The threshold of the actuation voltage was determined for all dielectric materials of varying thicknesses. Additionally, the OpenDrop device was tested by utilizing a single-plate system to transport microliter droplets for a bioassay operation. With the newly proposed fabrication methods, these dielectric materials showed changes in contact angle and droplet velocity when the actuation voltage was applied. The threshold actuation voltage for the dielectric layers of 10–13 μm was 190 V for the open plate DMFBs. View Full-Text
Keywords: digital microfluidic biochips; electrowetting-on-dielectric; printed circuit board; droplet actuation digital microfluidic biochips; electrowetting-on-dielectric; printed circuit board; droplet actuation
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Zulkepli, S.N.I.S.; Hamid, N.H.; Shukla, V. Droplet Velocity Measurement Based on Dielectric Layer Thickness Variation Using Digital Microfluidic Devices. Biosensors 2018, 8, 45.

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