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Biosensors 2018, 8(2), 40; https://doi.org/10.3390/bios8020040

S-Layer Protein-Based Biosensors

Institute for Synthetic Bioarchitectures, Department of NanoBiotechnology, University of Natural Resources and Life Sciences, Vienna, Muthgasse 11, 1190 Vienna, Austria
Received: 9 March 2018 / Revised: 5 April 2018 / Accepted: 9 April 2018 / Published: 11 April 2018
(This article belongs to the Special Issue Micro and Nanoscale Biosensors)
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Abstract

The present paper highlights the application of bacterial surface (S-) layer proteins as versatile components for the fabrication of biosensors. One technologically relevant feature of S-layer proteins is their ability to self-assemble on many surfaces and interfaces to form a crystalline two-dimensional (2D) protein lattice. The S-layer lattice on the surface of a biosensor becomes part of the interface architecture linking the bioreceptor to the transducer interface, which may cause signal amplification. The S-layer lattice as ultrathin, highly porous structure with functional groups in a well-defined special distribution and orientation and an overall anti-fouling characteristics can significantly raise the limit in terms of variety and the ease of bioreceptor immobilization, compactness of bioreceptor molecule arrangement, sensitivity, specificity, and detection limit for many types of biosensors. The present paper discusses and summarizes examples for the successful implementation of S-layer lattices on biosensor surfaces in order to give a comprehensive overview on the application potential of these bioinspired S-layer protein-based biosensors. View Full-Text
Keywords: biosensor; S-layer protein; crystalline 2D protein lattice; lipid membrane platform; linking matrix; bioreceptor; biomimetics biosensor; S-layer protein; crystalline 2D protein lattice; lipid membrane platform; linking matrix; bioreceptor; biomimetics
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Schuster, B. S-Layer Protein-Based Biosensors. Biosensors 2018, 8, 40.

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