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Biosensors 2018, 8(1), 4; https://doi.org/10.3390/bios8010004

A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution

1
Department of Chemical and Biomolecular Engineering and Electronics Design Center, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
2
Dipartimento di Chimica Materiali ed Ingegneria Chimica “Giulio Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milano, Italy
3
Swagelok Center for Surface Analysis of Materials (SCSAM), Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
*
Author to whom correspondence should be addressed.
Received: 8 November 2017 / Revised: 2 January 2018 / Accepted: 4 January 2018 / Published: 6 January 2018
(This article belongs to the Special Issue Continuous Glucose Monitoring)
View Full-Text   |   Download PDF [4022 KB, uploaded 6 January 2018]   |  

Abstract

A cuprous oxide (Cu2O) thin layer served as the base for a non-enzymatic glucose sensor in an alkaline medium, 0.1 NaOH solution, with a linear range of 50–200 mg/dL using differential pulse voltammetry (DPV) measurement. An X-ray photoelectron spectroscopy (XPS) study confirmed the formation of the cuprous oxide layer on the thin gold film sensor prototype. Quantitative detection of glucose in both phosphate-buffered saline (PBS) and undiluted human serum was carried out. Neither ascorbic acid nor uric acid, even at a relatively high concentration level (100 mg/dL in serum), interfered with the glucose detection, demonstrating the excellent selectivity of this non-enzymatic cuprous oxide thin layer-based glucose sensor. Chronoamperometry and single potential amperometric voltammetry were used to verify the measurements obtained by DPV, and the positive results validated that the detection of glucose in a 0.1 M NaOH alkaline medium by DPV measurement was effective. Nickel, platinum, and copper are commonly used metals for non-enzymatic glucose detection. The performance of these metal-based sensors for glucose detection using DPV were also evaluated. The cuprous oxide (Cu2O) thin layer-based sensor showed the best sensitivity for glucose detection among the sensors evaluated. View Full-Text
Keywords: cuprous oxide; non-enzymatic glucose sensor; alkaline solution; differential pulse voltammetry cuprous oxide; non-enzymatic glucose sensor; alkaline solution; differential pulse voltammetry
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Dai, Y.; Molazemhosseini, A.; Abbasi, K.; Liu, C.C. A Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry and Other Voltammetry Methods and a Comparison to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution. Biosensors 2018, 8, 4.

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