Next Article in Journal
Advances in Enzyme-Based Biosensors for Pesticide Detection
Previous Article in Journal
The Use of Biosensors to Explore the Potential of Probiotic Strains to Reduce the SOS Response and Mutagenesis in Bacteria
Previous Article in Special Issue
Mining the Potential of Label-Free Biosensors for In Vitro Antipsychotic Drug Screening
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessFeature PaperArticle
Biosensors 2018, 8(1), 26; https://doi.org/10.3390/bios8010026

Fabrication of SrTiO3 Layer on Pt Electrode for Label-Free Capacitive Biosensors

1
Department of Industrial Engineering, University of Salerno, 84084 Fisciano, Italy
2
Department of Physics “ER Caianiello”, University of Salerno, 84084 Fisciano, Italy
3
Institute of Superconducting oxides and other innovative materials and devices of the National Council of Research (CNR), Unit Operative of Salerno, 84084 Fisciano, Italy
4
Institute of Crystallography of the National Council of Research (CNR), 00015 Monterotondo Scalo, Italy
*
Author to whom correspondence should be addressed.
Received: 22 February 2018 / Revised: 9 March 2018 / Accepted: 13 March 2018 / Published: 16 March 2018
(This article belongs to the Special Issue Label-free Biosensing)
View Full-Text   |   Download PDF [2872 KB, uploaded 3 May 2018]   |  

Abstract

Due to their interesting ferroelectric, conductive and dielectric properties, in recent years, perovskite-structured materials have begun to attract increasing interest in the biosensing field. In this study, a strontium titanate perovskite layer (SrTiO3) has been synthesized on a platinum electrode and exploited for the development of an impedimetric label-free immunosensor for Escherichia coli O157:H7 detection. The electrochemical characterization of the perovskite-modified electrode during the construction of the immunosensor, as well as after the interaction with different E. coli O157:H7 concentrations, showed a reproducible decrease of the total capacitance of the system that was used for the analytical characterization of the immunosensor. Under optimized conditions, the capacitive immunosensor showed a linear relationship from to 1 to 7 log cfu/mL with a low detection limit of 1 log cfu/mL. Moreover, the atomic force microscopy (AFM) technique underlined the increase in roughness of the SrTiO3-modified electrode surface after antibody immobilization, as well as the effective presence of cells with the typical size of E. coli. View Full-Text
Keywords: biosensors; label-free; perovskite; strontium titanium oxide biosensors; label-free; perovskite; strontium titanium oxide
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Malvano, F.; Maritato, L.; Carapella, G.; Orgiani, P.; Pilloton, R.; Di Matteo, M.; Albanese, D. Fabrication of SrTiO3 Layer on Pt Electrode for Label-Free Capacitive Biosensors. Biosensors 2018, 8, 26.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biosensors EISSN 2079-6374 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top