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Biosensors 2017, 7(4), 57; doi:10.3390/bios7040057

Study of SH-SY5Y Cancer Cell Response to Treatment with Polyphenol Extracts Using FT-IR Spectroscopy

Dipartimento di Fisica “Ettore Pancini”, Università di Napoli “Federico II”, 80126 Napoli, Italy
Dipartimento di Medicina Sperimentale, Università della Campania “Luigi Vanvitelli”, 80138 Napoli, Italy
Dipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Università della Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
Author to whom correspondence should be addressed.
Received: 19 September 2017 / Revised: 28 November 2017 / Accepted: 28 November 2017 / Published: 30 November 2017
(This article belongs to the Collection Raman and IR Spectroscopic Sensing)
View Full-Text   |   Download PDF [4006 KB, uploaded 30 November 2017]   |  


Plant polyphenols are important components of human diet and a number of them are considered to possess chemo-preventive and therapeutic properties against cancer. They are recognized as naturally occurring antioxidants, but also as pro-oxidant, pro-apoptotic, or chromosomal aberrations inducers, depending on their concentration and/or the stage of cell-cycle of the cells with which they interact. For these reasons, particular interest is devoted to knowing the total effects of polyphenols on the cell cycle and metabolism. Fourier-Transform Infrared (FT-IR) spectroscopy thanks to its ability in analyzing cells at a molecular level can be particularly useful in investigating the biochemical changes induced in protein, nucleic acid, lipid, and carbohydrate content of cells by means of polyphenols administration. Spectroscopic analysis was performed on in vitro human SH-SY5Y neuroblastoma cells that were exposed to different doses of a cherry derived polyphenol extract. The infrared spectra that were obtained from unexposed and exposed cells show significant differences that can be helpful in order to understand the cells-polyphenols interaction. View Full-Text
Keywords: plant polyphenols; neuroblastoma cells; Fourier-Transform Infrared microspectroscopy; cells-polyphenols interaction plant polyphenols; neuroblastoma cells; Fourier-Transform Infrared microspectroscopy; cells-polyphenols interaction

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ricciardi, V.; Portaccio, M.; Piccolella, S.; Manti, L.; Pacifico, S.; Lepore, M. Study of SH-SY5Y Cancer Cell Response to Treatment with Polyphenol Extracts Using FT-IR Spectroscopy. Biosensors 2017, 7, 57.

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