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Biosensors 2017, 7(4), 53; doi:10.3390/bios7040053

Central [CNS] and Peripheral [Gastric Tissue] Selective Monitoring of Somatostatin (SRIF) with Micro-Sensor and Voltammetry in Rats: Influence of Growth Factors (GH, EGF)

Biology, GSK, via Fleming 4, 37135 Verona, Italy
Received: 5 October 2017 / Revised: 11 November 2017 / Accepted: 14 November 2017 / Published: 17 November 2017
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Abstract

Somatostatin (SRIF) is widely distributed throughout the body, and regulates the endocrine system via interactions with various hormones, including the pituitary growth hormone, the thyroid stimulating hormone and the majority of the hormones of the gastrointestinal tract. SRIF is present in the central nervous system (CNS), where it affects rates of neurotransmission, and is also reported to be active in the intestinal tract, with evidence that stressed rats present a significant decrease in antral somatostatin-like immunoreactivity (SLI). Analysis of SRIF has mainly been carried out by means of radioimmunoassay methods. Here, we propose the use of an electrochemical method, such as voltammetry, applied with carbon-based sensors and, in particular, the combination of differential pulse voltammetry with treated carbon fiber micro electrodes (DPV-µCFE) to facilitate the analysis of such peptidergic electro active hormones in the rat striatum and gastric tissue; the effect of growth hormone (GH) and epidermal growth factor (EGF), in particular, upon the SRIF signal has been studied in such tissues. View Full-Text
Keywords: somatostatin (SRIF); rat; CNS; stomach; differential pulse voltammetry (DPV) carbon fiber micro-electrode (µCFE); growth factors somatostatin (SRIF); rat; CNS; stomach; differential pulse voltammetry (DPV) carbon fiber micro-electrode (µCFE); growth factors
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MDPI and ACS Style

Crespi, F. Central [CNS] and Peripheral [Gastric Tissue] Selective Monitoring of Somatostatin (SRIF) with Micro-Sensor and Voltammetry in Rats: Influence of Growth Factors (GH, EGF). Biosensors 2017, 7, 53.

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