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Biosensors 2017, 7(4), 49; doi:10.3390/bios7040049

Strategies Using Bio-Layer Interferometry Biosensor Technology for Vaccine Research and Development

Pall Fortebio, 47661 Fremont Boulevard, Fremont, CA 94538, USA
Received: 14 September 2017 / Revised: 26 October 2017 / Accepted: 28 October 2017 / Published: 31 October 2017
(This article belongs to the Special Issue Label-free Biosensing)
View Full-Text   |   Download PDF [3459 KB, uploaded 31 October 2017]   |  

Abstract

Bio-layer interferometry (BLI) real-time, label-free technology has greatly contributed to advances in vaccine research and development. BLI Octet platforms offer high-throughput, ease of use, reliability, and high precision analysis when compared with common labeling techniques. Many different strategies have been used to immobilize the pathogen or host molecules on BLI biosensors for real-time kinetics and affinity analysis, quantification, or high-throughput titer. These strategies can be used in multiple applications and shed light onto the structural and functional aspects molecules play during pathogen-host interactions. They also provide crucial information on how to achieve protection. This review summarizes some key BLI strategies used in human vaccine research and development. View Full-Text
Keywords: BLI; vaccine; biosensor; label-free; real-time BLI; vaccine; biosensor; label-free; real-time
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Petersen, R.L. Strategies Using Bio-Layer Interferometry Biosensor Technology for Vaccine Research and Development. Biosensors 2017, 7, 49.

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