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Biosensors 2016, 6(3), 40; doi:10.3390/bios6030040

Monitoring Intact Viruses Using Aptamers

Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology, 1-1-1 Higashi, Tsukuba City 305-8566, Ibaraki, Japan
Academic Editor: Giovanna Marrazza
Received: 27 June 2016 / Revised: 27 July 2016 / Accepted: 29 July 2016 / Published: 4 August 2016
(This article belongs to the Special Issue Aptamer Sensors)
View Full-Text   |   Download PDF [3174 KB, uploaded 4 August 2016]   |  

Abstract

Viral diagnosis and surveillance are necessary steps in containing the spread of viral diseases, and they help in the deployment of appropriate therapeutic interventions. In the past, the commonly employed viral detection methods were either cell-culture or molecule-level assays. Most of these assays are laborious and expensive, require special facilities, and provide a slow diagnosis. To circumvent these limitations, biosensor-based approaches are becoming attractive, especially after the successful commercialization of glucose and other biosensors. In the present article, I have reviewed the current progress using the biosensor approach for detecting intact viruses. At the time of writing this review, three types of bioreceptor surfaces (antibody-, glycan-, and aptamer-based) have been explored on different sensing platforms for detecting intact viruses. Among these bioreceptors, aptamer-based sensors have been increasingly explored for detecting intact viruses using surface plasmon resonance (SPR) and other platforms. Special emphasis is placed on the aptamer-based SPR platform in the present review. View Full-Text
Keywords: virus; antibodies; glycans; aptamer; biosensor; and surface plasmon resonance virus; antibodies; glycans; aptamer; biosensor; and surface plasmon resonance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kumar, P.K.R. Monitoring Intact Viruses Using Aptamers. Biosensors 2016, 6, 40.

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