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Biosensors 2016, 6(2), 12; doi:10.3390/bios6020012

Epigenome: A Biomarker or Screening Tool to Evaluate Health Impact of Cumulative Exposure to Chemical and Non-Chemical Stressors

National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC 20460, USA
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Author to whom correspondence should be addressed.
Academic Editor: Nastaran Hashemi
Received: 29 February 2016 / Revised: 28 March 2016 / Accepted: 29 March 2016 / Published: 1 April 2016
(This article belongs to the Special Issue Biosensors in Environmental Studies)
View Full-Text   |   Download PDF [188 KB, uploaded 1 April 2016]

Abstract

Current risk assessment practices and toxicity information are hard to utilize for assessing the health impact of combined or cumulative exposure to multiple chemical and non-chemical stressors encountered in the “real world” environment. Non-chemical stressors such as heat, radiation, noise, humidity, bacterial and viral agents, and social factors, like stress related to violence and socioeconomic position generally cannot be currently incorporated into the risk assessment paradigm. The Science and Decisions report released by the National Research Council (NRC) in 2009 emphasized the need to characterize the effects of multiple stressors, both chemical and non-chemical exposures. One impediment to developing information relating such non-chemical stressors to health effects and incorporating them into cumulative assessment has been the lack of analytical tools to easily and quantitatively monitor the cumulative exposure to combined effects of stressors over the life course. View Full-Text
Keywords: chemical; cumulative; DNA methylation; environmental; epigenetics; epigenome; non-chemical; histone modification; stressors chemical; cumulative; DNA methylation; environmental; epigenetics; epigenome; non-chemical; histone modification; stressors
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Olden, K.; Lin, Y.-S.; Bussard, D. Epigenome: A Biomarker or Screening Tool to Evaluate Health Impact of Cumulative Exposure to Chemical and Non-Chemical Stressors. Biosensors 2016, 6, 12.

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