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Nanomaterials 2018, 8(6), 429; https://doi.org/10.3390/nano8060429 (registering DOI)

Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose

1
Department of Chemistry, Chung-Yuan Christian University, Chungli District, Taoyuan City 32023, Taiwan
2
Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, No. 1, Sec. 3, Chung-Hsiao East Rd., Taipei 106, Taiwan
3
R&D Center for Membrane Technology, Chung-Yuan Christian University, Chungli District, Taoyuan City 32023, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 19 May 2018 / Revised: 4 June 2018 / Accepted: 10 June 2018 / Published: 13 June 2018
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Abstract

Copper nanoparticles with the diameter of 50 ± 20 nm decorated nitrogen doped graphite oxide (NGO) have been prepared through a simple single step carbonization method using copper metal-organic framework (MOF), [Cu2(BDC)2(DABCO)] (where BDC is 1,4-benzenedicarboxylate, and DABCO is 1,4-Diazabicyclo[2.2.2]octane) as precursor. The surface morphology, porosity, surface area and elemental composition of CuNPs/NGO were characterized by various techniques. The as-synthesized CuNPs/NGO nanomaterials were coated on commercially available disposable screen-printed carbon electrode for the sensitive determination of glucose. We find that the modified electrode can detect glucose between 1 μM and 1803 μM (linear range) with good sensitivity (2500 μA mM−1 cm−2). Our glucose sensor also possesses low limits of detection (0.44 μM) towards glucose determination. The highly selective nature of the fabricated electrode was clearly visible from the selectivity studies. The practicability of CuNPs/NGO modified electrode has been validated in the human serum samples. The storage stability along with better repeatability and reproducibility results additionally substantiate the superior electrocatalytic activity of our constructed sensor towards glucose. View Full-Text
Keywords: metal-organic framework; copper nanoparticles; nitrogen doped graphite oxide; amperometric techniques; glucose; human serum samples metal-organic framework; copper nanoparticles; nitrogen doped graphite oxide; amperometric techniques; glucose; human serum samples
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sivasankar, K.; Rani, K.K.; Wang, S.-F.; Devasenathipathy, R.; Lin, C.-H. Copper Nanoparticle and Nitrogen Doped Graphite Oxide Based Biosensor for the Sensitive Determination of Glucose. Nanomaterials 2018, 8, 429.

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