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Nanomaterials 2018, 8(6), 401; https://doi.org/10.3390/nano8060401

Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice

1
Department of Radiology, Sismanoglio General Hospital of Attica, Sismanogliou 1, Marousi 15126, Greece
2
Università degli Studi di Milano, Dipartimento di Fisica, Via Celoria 16, 20133 Milano, Italy
3
ICCOM-CNR via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy
4
INSTM and Dept. Of Chemistry “U. Schiff”, University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
The authors dedicate this review article to the memory of our dearest friend and colleague Maria De Deus Carvalho, from the University of Lisbon, Portugal.
*
Author to whom correspondence should be addressed.
Received: 29 April 2018 / Revised: 30 May 2018 / Accepted: 1 June 2018 / Published: 3 June 2018
(This article belongs to the Special Issue Magnetic Nanoparticles in Biological Applications)
View Full-Text   |   Download PDF [342 KB, uploaded 3 June 2018]

Abstract

Hyperthermia, though by itself generally non-curative for cancer, can significantly increase the efficacy of radiation therapy, as demonstrated by in vitro, in vivo, and clinical results. Its limited use in the clinic is mainly due to various practical implementation difficulties, the most important being how to adequately heat the tumor, especially deep-seated ones. In this work, we first review the effects of hyperthermia on tissue, the limitations of radiation therapy and the radiobiological rationale for combining the two treatment modalities. Subsequently, we review the theory and evidence for magnetic hyperthermia that is based on magnetic nanoparticles, its advantages compared with other methods of hyperthermia, and how it can be used to overcome the problems associated with traditional techniques of hyperthermia. View Full-Text
Keywords: hyperthermia; radiation therapy; magnetic nanoparticles; magnetic fluid hyperthermia; nanomedicine; cancer therapy hyperthermia; radiation therapy; magnetic nanoparticles; magnetic fluid hyperthermia; nanomedicine; cancer therapy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Spirou, S.V.; Basini, M.; Lascialfari, A.; Sangregorio, C.; Innocenti, C. Magnetic Hyperthermia and Radiation Therapy: Radiobiological Principles and Current Practice . Nanomaterials 2018, 8, 401.

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