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Nanomaterials 2018, 8(5), 324; https://doi.org/10.3390/nano8050324

Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing

1
College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
2
College of Agronomy and Resources Environment, Tianjin Agricultural University, Tianjin 300384, China
3
Key Laboratory of Advanced Textile Composites, Ministry of Education; School of Textiles, Tianjin Polytechnic University, Tianjin 300387, China
These authors contribute equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 13 April 2018 / Revised: 28 April 2018 / Accepted: 7 May 2018 / Published: 14 May 2018
(This article belongs to the Special Issue Nanoscale Materials and Technologies in Tissue Engineering)
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Abstract

In wound care management, the prevention of wound infection and the retention of an appropriate level of moisture are two major challenges. Therefore, designing an excellent antibacterial hydrogel with a suitable water-adsorbing capacity is very important to improve the development of wound dressings. In this paper, a novel silver nanoparticles/poly (gamma-glutamic acid) (γ-PGA) composite dressing was prepared for biomedical applications. The promoted wound-healing ability of the hydrogels were systematically evaluated with the aim of attaining a novel and effective wound dressing. A diffusion study showed that hydrogels can continuously release antibacterial factors (Ag). Hydrogels contain a high percentage of water, providing an ideal moist environment for tissue regeneration, while also preventing contraction of the wound. Moreover, an in vivo, wound-healing model evaluation of artificial wounds in mice indicated that silver/γ-PGA hydrogels could significantly promote wound healing. Histological examination revealed that hydrogels can successfully help to reconstruct intact epidermis and collagen deposition during 14 days of impaired wound healing. Overall, this research could shed new light on the design of antibacterial silver/γ-PGA hydrogels with potential applications in wound dressing. View Full-Text
Keywords: biomedical; Ag nanoparticles; poly (gamma-glutamic acid) hydrogel; wound healing biomedical; Ag nanoparticles; poly (gamma-glutamic acid) hydrogel; wound healing
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Wang, Y.; Dou, C.; He, G.; Ban, L.; Huang, L.; Li, Z.; Gong, J.; Zhang, J.; Yu, P. Biomedical Potential of Ultrafine Ag Nanoparticles Coated on Poly (Gamma-Glutamic Acid) Hydrogel with Special Reference to Wound Healing. Nanomaterials 2018, 8, 324.

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