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Nanomaterials 2017, 7(6), 138; doi:10.3390/nano7060138

Designed Synthesis of Nanostructured Magnetic Hydroxyapatite Based Drug Nanocarrier for Anti-Cancer Drug Delivery toward the Treatment of Human Epidermoid Carcinoma

1
Department of Chemistry, Alfaisal University, P.O. Box 50927, Riyadh 11533, Saudi Arabia
2
Department of Nanoscience and Technology, Bharathiar University, Coimbatore 641046, India
3
Department of Biotechnology, Indian Institute of Technology Madras, Chennai-600036, Tamil Nadu, India
4
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
*
Authors to whom correspondence should be addressed.
Academic Editor: Thomas Nann
Received: 20 March 2017 / Revised: 19 May 2017 / Accepted: 24 May 2017 / Published: 6 June 2017
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Abstract

Superparamagnetic Fe3O4 nanoparticles on hydroxyapatite nanorod based nanostructures (Fe3O4/HAp) were synthesized using hydrothermal techniques at 180 °C for 12 h and were used as drug delivery nanocarriers for cancer cell therapeutic applications. The synthesized Fe3O4/HAp nanocomposites were characterized by X-ray diffraction analysis (XRD), Field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET)-analysis, and vibrating sample magnetometry (VSM). The morphologies of the Fe3O4/HAp nanocomposites show 15 nm Fe3O4 nanoparticles dispersed in the form of rods. The BET result shows that the synthesized samples have a high specific surface area of 80 m2 g−1 with mesoporous structures. Magnetic measurements revealed that the sample has high saturation magnetization of 18 emu/g with low coercivity. The Fe3O4/HAp nanocomposites had a large specific surface area (SSA), high mesoporous volume, and good magnetic property, which made it a suitable nanocarrier for targeted drug delivery systems. The chemotherapeutic agent, andrographolide, was used to investigate the drug delivery behavior of the Fe3O4/HAp nanocomposites. The human epidermoid skin cancer cells (A431) were used as the model targeting cell lines by treating with andrographolide loaded Fe3O4/HAp nanosystems and were further evaluated for their antiproliferative activities and the induction of apoptosis. Also, the present nanocomposite shows better biocompatibility, therefore it can be used as suitable drug vehicle for cancer therapy applications. View Full-Text
Keywords: magnetic hydroxyapatite nanocomposites; cytotoxicity; human skin cancer; drug nanocarrier; andrographolide magnetic hydroxyapatite nanocomposites; cytotoxicity; human skin cancer; drug nanocarrier; andrographolide
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Govindan, B.; Swarna Latha, B.; Nagamony, P.; Ahmed, F.; Saifi, M.A.; Harrath, A.H.; Alwasel, S.; Mansour, L.; Alsharaeh, E.H. Designed Synthesis of Nanostructured Magnetic Hydroxyapatite Based Drug Nanocarrier for Anti-Cancer Drug Delivery toward the Treatment of Human Epidermoid Carcinoma. Nanomaterials 2017, 7, 138.

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