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Recent Advances in Nanomaterials for Gene Delivery—A Review
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Nanomaterials 2017, 7(6), 120; doi:10.3390/nano7060120

Trigger-Responsive Gene Transporters for Anticancer Therapy

1
Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Chonnam National University Medical School, Gwangju 61469, Korea
2
Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
Academic Editors: Thomas Nann and Fani Sousa
Received: 3 April 2017 / Revised: 5 May 2017 / Accepted: 19 May 2017 / Published: 26 May 2017
(This article belongs to the Special Issue Nanomaterials in Gene Therapy)
View Full-Text   |   Download PDF [4170 KB, uploaded 26 May 2017]   |  

Abstract

In the current era of gene delivery, trigger-responsive nanoparticles for the delivery of exogenous nucleic acids, such as plasmid DNA (pDNA), mRNA, siRNAs, and miRNAs, to cancer cells have attracted considerable interest. The cationic gene transporters commonly used are typically in the form of polyplexes, lipoplexes or mixtures of both, and their gene transfer efficiency in cancer cells depends on several factors, such as cell binding, intracellular trafficking, buffering capacity for endosomal escape, DNA unpacking, nuclear transportation, cell viability, and DNA protection against nucleases. Some of these factors influence other factors adversely, and therefore, it is of critical importance that these factors are balanced. Recently, with the advancements in contemporary tools and techniques, trigger-responsive nanoparticles with the potential to overcome their intrinsic drawbacks have been developed. This review summarizes the mechanisms and limitations of cationic gene transporters. In addition, it covers various triggers, such as light, enzymes, magnetic fields, and ultrasound (US), used to enhance the gene transfer efficiency of trigger-responsive gene transporters in cancer cells. Furthermore, the challenges associated with and future directions in developing trigger-responsive gene transporters for anticancer therapy are discussed briefly. View Full-Text
Keywords: cationic polymer; gene delivery; non-viral; anti-cancer; trigger-responsive; photothermal; glutathione; ultrasound; magnetic field cationic polymer; gene delivery; non-viral; anti-cancer; trigger-responsive; photothermal; glutathione; ultrasound; magnetic field
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Rajendrakumar, S.K.; Uthaman, S.; Cho, C.S.; Park, I.-K. Trigger-Responsive Gene Transporters for Anticancer Therapy. Nanomaterials 2017, 7, 120.

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