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Nanomaterials 2017, 7(4), 87; doi:10.3390/nano7040087

Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules

1,2,†,* , 2,†
,
1
,
1
,
1
and
2,*
1
Institute of Environmental and Analysis Science, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, Henan, China
2
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
The authors contributed equally.
*
Authors to whom correspondence should be addressed.
Academic Editors: Nicola Cioffi and Thomas Nann
Received: 26 March 2017 / Revised: 12 April 2017 / Accepted: 19 April 2017 / Published: 21 April 2017
(This article belongs to the Special Issue Nanomaterials for Mass Spectrometry Applications)
View Full-Text   |   Download PDF [2460 KB, uploaded 21 April 2017]   |  

Abstract

Matrix-assisted laser desorption/ionization (MALDI), a soft ionization method, coupling with time-of-flight mass spectrometry (TOF MS) has become an indispensible tool for analyzing macromolecules, such as peptides, proteins, nucleic acids and polymers. However, the application of MALDI for the analysis of small molecules (<700 Da) has become the great challenge because of the interference from the conventional matrix in low mass region. To overcome this drawback, more attention has been paid to explore interference-free methods in the past decade. The technique of applying nanomaterials as matrix of laser desorption/ionization (LDI), also called nanomaterial-assisted laser desorption/ionization (nanomaterial-assisted LDI), has attracted considerable attention in the analysis of low-molecular weight compounds in TOF MS. This review mainly summarized the applications of different types of nanomaterials including carbon-based, metal-based and metal-organic frameworks as assisted matrices for LDI in the analysis of small biological molecules, environmental pollutants and other low-molecular weight compounds. View Full-Text
Keywords: nanomaterial; laser desorption/ionization; time-of-flight mass spectrometry; small biological molecules; environmental pollutants nanomaterial; laser desorption/ionization; time-of-flight mass spectrometry; small biological molecules; environmental pollutants
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Lu, M.; Yang, X.; Yang, Y.; Qin, P.; Wu, X.; Cai, Z. Nanomaterials as Assisted Matrix of Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Analysis of Small Molecules. Nanomaterials 2017, 7, 87.

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